• Original article (Basic research) •
ZHAI Tian-hang , ZHANG Jie, LI Hui-dan, HUO Rong-fen, SHEN Bai-hua, LI Ning-li
National Natural Science Foundation of China，81172856; Foundation of Science and Technology Commission of Shanghai Municipality， 12JC1407700，12401903702
Objective To investigate the correlation between the expression of hypoxia-inducible factor-1α (HIF-1α) and the expression of matrix metalloproteinases (MMPs) in synovial tissues of patients with rheumatoid arthritis (RA). Methods The expressions of HIF-1α and MMPs in synovial tissues of patients with RA and osteoarthritis (OA) were detected by real-time PCR and the correlation analysis was conducted. Results The mRNA expressions of HIF-1α, MMP-1, MMP-3, MMP-9, and MMP-13 in synovial tissues of patients with RA were significantly higher than those of patients with OA. Highly expressed HIF-1α in synovial tissues of patients with RA significantly and positively correlated with MMP-9. Conclusion Highly expressed HIF-1α in synovial tissues of patients with RA may involve in the regulation of the expression of MMP-9 and the process of pathological change of RA.
ZHAI Tian-hang,ZHANG Jie, LI Hui-dan, et al. Correlation between HIF-1α and MMPs in synovial tissues of patients with rheumatoid arthritis[J]. , doi: 10.3969/j.issn.1674-8115.2015.09.002.
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