›› 2015, Vol. 35 ›› Issue (10): 1526-.doi: 10.3969/j.issn.1674-8115.2015.10.019

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Correlation between variations of event-related potentials and clinical symptoms of patients with first-episode schizophrenia and recur

SONG Li-sheng1,CHEN Xing-shi2, CHEN Mei-juan1, LU Zheng3, SHI Shen-xun4, YI Zheng-hui1, YANG Wei-min1, XU hua1, LONG Bin1, WU Guo-jun1, XIE Fan1, HE Yong-guang1, HU Guo-qin1, WU Rong-qin5, TANG Jia-lin5     

  1. 1.Department of Psychiatry, 2.Department of Neuroelectrophysiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China; 3.Department of Psychiatry, Tongji Hospital, Tongji University, Shanghai200065, China; 4.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai200040, China; 5.Department of Psychiatry, Shanghai Zhabei Mental Health Center, Shanghai200436, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    Shanghai Shenkang Hospital Development Project, SHDC12013116; Shanghai Shenkang Municipal Hospital Appropriate Technology Promoting and Application Project, SHDC12012234; Shanghai Health System Appropriate Technology Promotion Plan, 2013SY069


ObjectiveTo investigate the correlation between variations of event-related potentials and clinical symptoms of patients with first-episode schizophrenia (FSE) and recur schizophrenia (RSZ), features of variations, and relevant mechanisms.MethodsP3 values of 96 patients with FSE (FSE group),118 patients with RSE (RSE group), and 110 controls (control group) were measured by Brova cerebral electrophysiological instrument and auditory target-non target stimulus sequence technique. Psychotic symptoms of patients were assessed by the positive and negative syndrome scale (PANSS). P3 values of the case group were followed up after being treated for 6 weeks.ResultsThe prolonged latency and decreased amplitude of P3 in Cz brain region of patients with FSZ and RSZ negatively correlated with the score of positive syndrome and total score of PANSS. For target latency of N2, P3, and non target P2, the differences of amplitudes of P3 and non target P2 of three groups were statistically significant (P<0.05, P<0.01). Compared with the control group, latencies of N2 and P3 of the FSZ group and RSZ group delayed and amplitudes of P3 decreased (P<0.05, P<0.01). Compared with the FSZ group, non target P2 of the FSZ group delayed and the amplitude of non target P2 decreased (P<0.05). The amplitude of target P3 of the FSZ group recovered after treatment, while that of the RSZ group didn’t recover. The amplitude of P3 of the RSZ group recovered poorly after treatment. Follow up results of patients with FSZ and RSZ showed that delayed latencies of N2 and P3 might be feature markers of the disease, while decreased amplitudes of target P2 and P3 might be state markers of the disease.ConclusionCognitive deficits can be found at the onset of schizophrenia, which may affect the future incidence, therapeutic effect, and society function. Follow up results indicate that changes of P3 may be mixed markers of schizophrenia.

Key words: schizophrenia, first-episode, recur, P3, mixed marker