›› 2015, Vol. 35 ›› Issue (10): 1581-.doi: 10.3969/j.issn.1674-8115.2015.10.030

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Application of resting-state functional magnetic resonance imaging to exploring connectivity of brain network of patients with obsessive compulsive disorder

ZHAO Qing, HU Hao, WANG Zhen   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    Medicine Guidance Project of Science and Technology Commission of Shanghai Municipality,124119a8601; Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University, YG2013MS65; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873

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Abstract:

Obsessive compulsive disorder (OCD) is a chronic disabling mental illness. Researches have revealed the abnormal connectivity of brain network. Resting-state functional magnetic resonance imaging (R-fMRI) is a powerful tool to explore the pathogenesis of OCD and other mental disorders. Seed-based analysis of interested region, independent component analysis (ICA), and graph theory-based analysis are popular methods to quantify brain network by R-fMRI data. This paper reviews current studies on connectivity of brain network of OCD by above methods and research progresses.

Key words: resting-state functional magnetic resonance imaging, obsessive compulsive  , disorder, region of interest, independent component analysis, graph theory