›› 2015, Vol. 35 ›› Issue (10): 1585-.doi: 10.3969/j.issn.1674-8115.2015.10.031

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Advances of γ-aminobutyric acid of patients with schizophrenia by proton magnetic resonance spectroscopy

WANG Jun-jie, TANG Ying-ying, WANG Ji-jun   

  1. Department of EEG Source Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    Project of Brain Diseases Clinical Research Center, Shanghai Jiao Tong University School of Medicine， 20150626; Shanghai Health System Advanced Appropriate Technology Promotion Project， 2013SY003; Medical Guide Project of Shanghai Science and Technology Commission， 14411961400

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Abstract:

Schizophrenia is a common severe mental illness with high rate of relapse and disability, but the pathogenesis is unknown. Gama-aminobutyric acid (GABA) is the major inhibitory neurotransmitter, which is relevant to pathophysiological mechanisms of schizophrenia. Proton magnetic resonance spectroscopy is a non-invasive technique for directly measuring the regional GABA level of patient’s brain in vivo, which provides a novel idea for investigating the pathogenesis of schizophrenia and developing new intervention measures. This paper reviews progresses of studying GABA of patients with schizophrenia by proton magnetic resonance spectroscopy.

Key words: schizophrenia, proton magnetic resonance spectroscopy, γ-aminobutyric acid