Abstract:

Objective To explore the correlation between the severity of coronary artery lesions and levels of glycated hemoglobin (HbA1c) and bilirubin (TBI) for patients with diabetes and coronary atherosclerotic cardiopathy (coronary heart disease for short). Methods A total of 124 patients with diabetes and coronary heart disease who treated in Shanghai Changhai Hospital from March 2010 to December 2014 were selected. Patients were divided into single-vessel lesion group (41 cases), double-vessel lesion group (42 cases), and three-vessel lesion group (41 cases) according to the severity of coronary artery lesions. The differences of HbA1c and TBI levels among three groups were compared. The correlation between levels of HbA1c and TBI and the severity of coronary artery lesions was analyzed. Results The differences of age, BMI, TC, TG, LDL, HDL, diabetes duration, HbA1c, fasting glucose, and TBI of three groups were statistically significant (P<0.05). The multivariate logistic regression analysis showed that duration of diabetes, HbA1c, and bilirubin were independent risk factors of the severity of coronary artery lesions (P<0.05). The severity of coronary artery lesions of patients with diabetes and coronary heart disease positively correlated to the level of HbA1c (r=0.337, P=0.000) and negatively correlated to the level of TBI (r=-0.372, P=0.000). Conclusion The severity of coronary artery lesions of patients with diabetes and coronary heart disease positively correlates to the level of HbA1c and negatively correlates to the level of TBI.

Key words: coronary atherosclerotic cardiopathy, diabetes mellitus, glycated hemoglobin, bilirubin