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Effects of ovarian function and menopausal hormone therapy on cognitive function

SUN Jun-yan, LAI Dong-mei   

  1. The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2016-09-28 Published:2016-10-31
  • Supported by:

    National Natural Science Foundation of China, 81370678; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support,20152236


Menopause is an inevitable natural event in a womans life and results from hypo-ovarianism. Symptoms such as osteoporosis, cardiovascular dysfunction, and urogenital tract atrophy are common in postmenopausal women. Menopausal hormone therapy (MHT) can remarkably improve the symptoms of menopause. Recent studies have shown that MHT is associated with cognitive function, while there are significant differences in approaches and results. This article explores several factors that significantly influence cognitive function, including therapeutic time window, type of menopause, baseline condition, and therapeutic regimen, so as to provide reference for the therapy opportunity choice of clinical MHT.

Key words: menopausal hormone therapy, cognition, ovarian function, therapeutic time window, menopausal type, baseline condition, therapeutic regimen