›› 2017, Vol. 37 ›› Issue (6): 865-.doi: 10.3969/j.issn.1674-8115.2017.06.026

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Progress on roles and mechanisms of CCAAT/enhancer binding protein β in endometrium decidualization

DI Fang-fang, LIU Jian-sheng, LI Shang, DU Yan-zhi   

  1. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152510

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Abstract:

 CCAAT/enhancer binding protein β (C/EBPβ) is a critical member of C/EBP family. C/EBPβ, based on the leucine zipper located in C terminal of the protein, can regulate transcriptional activities of downstream target genes involved in diverse cellular processes, such as proliferation and differentiation. Recently published studies have identified that C/EBPβ is essential in the decidualization of endometrial stromal cells. This review summarizes the roles and mechanisms of C/EBPβ during the courses of decidualization, which is aimed at providing novel insights for dysfunctional decidualization.

Key words: CCAAT/enhancer binding protein β, endometrial stromal cell, decidualization, proliferation, differentiation, cell cycle