›› 2017, Vol. 37 ›› Issue (9): 1271-.doi: 10.3969/j.issn.1674-8115.2017.09.014?

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Effect of autophagy on epithelia-mesenchymal transition

LI Bo-ning, LAI Dong-mei   

  1. The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2017-09-28 Published:2017-10-10
  • Supported by:
     National Natural Science Foundation of China, 81370678; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152236;Project of Shanghai Municipal Science and Technology Commission, 14411961500

Abstract:  Autophagy is a self-renewing cellular process by which defective proteins and aged organs are eliminated. It is noteworthy that autophagy correlates with the initiation and progression of cancer. During epithelial-mesenchymal transition (EMT), cells with epithelial phenotype gain mesenchymal characteristics, thus facilitate invasion and metastasis. Autophagy may suppress EMT by the following mechanisms, such as decreasing hypoxia inducible factor-1 (HIF-1) in hypoxia to downregulate transcription of EMT related genes, regulating TGF-β/Smad signaling pathway negatively, utilizing selective autophagy adaptor, p62, to modulate EMT transcription factors. Further studies of the association between autophagy and EMT may contribute to indentify new targets of cancer therapy.

Key words: autophagy, epithelial-mesenchymal transition, hypoxia-inducible factor 1, p62