›› 2019, Vol. 39 ›› Issue (9): 1065-.doi: 10.3969/j.issn.1674-8115.2019.09.020

• Original article (Clinical research) • Previous Articles     Next Articles

Correlation between plasma brain natriuretic peptide and functional outcome after intravenous thrombolysis in patients with acute ischemic stroke

ZHUANG Mei-ting, HE Xin-wei, ZHAO Rong, YIN Jia-wen, HU Yue, LIU Jian-ren   

  1. Department of Neurology, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200011, China
  • Online:2019-09-28 Published:2019-11-02
  • Supported by:
    Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20161422; Clinical Research Project of Shanghai Jiao Tong University School of Medicine, DLY201614; Chronic Disease Prevention and Treatment Project of Shanghai Hospital Development Center, SHDC12015310)。

Abstract: Objective · To study the correlation between brain natriuretic peptide (BNP) in plasma and functional outcome in patients with acute ischemic stroke after intravenous thrombolysis and its clinical significance. Methods · An analysis was performed on 141 cases of acute ischemic stroke patients with intravenous thrombolysis. According to the modified Rankin Scale (mRS) 3 months after thrombolysis, the patients were divided into the good outcome group (mRS ≤ 1) and the poor outcome group (mRS>1). BNP level indicators after thrombolysis were compared between the two groups. The receiver operator characteristic (ROC) curve was used to analyze the ability of BNP level to predict the functional outcome 3 months after thrombolysis, and the influence of some other relevant factors was adjustedLogistic regression analysis. Results · Compared with the good outcome group, the level of BNP in the poor outcome group was significantly increased (P0.003). According to ROC curve analysis, the elevated BNP level (BNP>202.6 pg/mL) had a certain predictive ability for poor functional outcome 3 months after intravenous thrombolysis in patients with acute ischemic stroke. Elevated BNP level was an independent predictor of functional outcome 3 months after intravenous thrombolysis in patients with acute ischemic stroke (OR2.406, 95% CI 1.0695.417, P0.034). Conclusion · Elevated plasma BNP level after thrombolysis is significantly associated with poor functional outcome in patients with acute ischemic stroke after intravenous thrombolysis, suggesting a predictive role of BNP for poor outcome 3 months after intravenous thrombolysis.

Key words: acute ischemic stroke, intravenous thrombolysis, brain natriuretic peptide

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