›› 2020, Vol. 40 ›› Issue (4): 534-.doi: 10.3969/j.issn.1674-8115.2020.04.020

• Review • Previous Articles     Next Articles

Effect of RNA N6-methyladenosine on immunoregulation

ZHU Xu-ying, LIN Qi-sheng, NI Zhao-hui   

  1. Department of Nephrology, Renji hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2020-04-28 Published:2020-05-22
  • Supported by:
    National Natural Science Foundation of China (81770666, 81570604); Foundation of Shanghai Municipal Commission of Health and Family Planning (201740037).

Abstract: N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional RNA modification in eukaryotes. m6A is a dynamic and reversible process catalyzedm6A methyltransferase complex and demethylase. m6A is involved in the regulations of gene and biological processes. Recently, researches have discovered that m6A plays a vital role in the differentiation and regulation of immune cells, which could provide a new idea for the research and therapy of immune-related diseases. The present article reviews the recent progresses of m6A in immunoregulation.

Key words: N6-methyladenosine, RNA modification, methyltransferase, demethylase, immune