JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (07): 968-973.doi: 10.3969/j.issn.1674-8115.2020.07.017

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Clinical progress of noninvasive follicular thyroid neoplasm with papillary-like nuclear features

ZENG Su, XU Pei-pei, GUO Ming-gao   

  1. Department of Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233
  • Online:2020-07-28 Published:2020-09-23
  • Supported by:
    National Natural Science Foundation of China (81672373).

Abstract: In 2015, the United States and Canadian Academy of Pathology re-evaluated noninvasive encapsulated follicular variant of papillary thyroid carcinomas (NI-EFVPC), and then the new terminology of "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) was initially introduced to replace NI-EFVPTC. In 2017, the World Health Organization also used NIFTP in the endocrine tumor classification. NIFTP is an encapsulated or clearly delimited noninvasive neoplasm with a follicular growth pattern and nuclear features of papillary thyroid carcinoma. Ultrasonography, cytology examination and genetic test are helpful to identify NIFTP, but the results overlap with invasive encapsulated follicular variant of papillary thyroid carcinoma. This paper mainly reviews the latest research in the clinical features, diagnosis and treatment features and prognosis of NIFTP.

Key words: noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), follicular variant of papillary thyroid carcinoma (FVPTC), clinical feature, diagnosis

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