Abstract: Major depressive disorder is usually associated with social and interpersonal dysfunction, which significantly affects the patients' daily life. This paper introduces problems of social and interpersonal interaction in the patients with major depressive disorder, and briefly reviews their abnormalities and neural mechanism in facial expression processing, social decision-making and social feedback processing, so as to give new ideas for the future research on intervention and treatment.

Key words: major depressive disorder, social and interpersonal dysfunction, facial expression processing, social decision-making, social feedback processing