JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (6): 830-833.doi: 10.3969/j.issn.1674-8115.2021.06.022

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Expression and significance of ATP-binding cassette superfamily G member 2 in lung cancer

Jian-hua XU1(), Ping JIANG1, Jiong DENG2()   

  1. 1.Department of Pathology and Pathophysiology, Kunming Medical University, Kunming 650032, China
    2.Key laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China
  • Online:2021-06-28 Published:2021-06-29
  • Contact: Jiong DENG;
  • Supported by:
    National Natural Science Foundation of China(81620108022)


The stemness and drug resistance of lung cancer cells are important features of malignancy. ATP-binding cassette superfamily G member 2 (ABCG2), a member of the ATP-binding cassette transporter family, is localized in the membrane of a variety of human cancer cells and excludes drugs from cells in an ATP-dependent manner. Single nucleotide polymorphisms in ABCG2 gene are significantly associated with multidrug resistance in cancer chemotherapy. In addition, ABCG2 has been used as a supporting biomarker for the identification of lung cancer stem cells. This review summarizes recent research progress in ABCG2, focusing on the regulation of ABCG2 gene expression, the potential roles of ABCG2 on cancer cell stemness, and the correlation of single nucleotide polymorphisms in ABCG2 with drug resistance in lung cancer, in order to provide a new strategy for the clinical treatment of lung cancer patients.

Key words: ATP-binding cassette superfamily G member 2 (ABCG2), lung cancer, stemness, drug resistance

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