Abstract:

Premature ventricular contraction-induced cardiomyopathy is a potentially reversible disease, and frequent premature ventricular contraction will cause left ventricular dysfunction and remodeling. Previous studies on adults and animal models have found that cardiac myocytes and extracellular mechanisms may be involved in the development of cardiac dysfunction, but the exact pathophysiological mechanism is still unclear. Moreover, there is no clear guidance for early diagnosis and intervention strategies in children. A series of adult studies have proved that a variety of high-risk factors lead to premature ventricular contraction-induced cardiomyopathy, including premature ventricular burden and ventricular premature contraction variability. However, studies on children are limited to case reports and retrospective, small-sample-size, single center series. This review summarizes and analyzes the high-risk factors of premature ventricular contraction-induced cardiomyopathy in children and the current intervention strategies.

Key words: premature ventricular contraction, cardiomyopathy, children, risk factor, treatment