JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (9): 1197-1206.doi: 10.3969/j.issn.1674-8115.2021.09.010
• Basic research • Previous Articles
Ying XU(), Yi-min CHU, Da-ming YANG, Ji LI, Hai-qin ZHANG, Hai-xia PENG(
)
Received:
2021-03-10
Online:
2021-08-24
Published:
2021-08-24
Contact:
Hai-xia PENG
E-mail:xy3459@shtrhospital.com;phx1101@shtrhospital.com
Supported by:
CLC Number:
Ying XU, Yi-min CHU, Da-ming YANG, Ji LI, Hai-qin ZHANG, Hai-xia PENG. Construction of a metastasis prediction model of microsatellite instability-high colorectal cancer based on differentially expressed gene assembly[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(9): 1197-1206.
Characteristic | Metastasis group (n=21) | Non-metastasis group (n=42) |
---|---|---|
Gender/n(%) | ||
Female | 12 (57.1) | 22 (52.4) |
Male | 9 (42.9) | 20 (47.6) |
Race/n(%) | ||
Unknown | 9 (42.9) | 7 (16.7) |
Asian | 0 (0) | 1 (2.4) |
Black or African American | 2 (9.5) | 7 (16.7) |
White | 10 (47.6) | 27 (64.3) |
Survival status/n(%) | ||
Alive | 17 (81.0) | 41 (97.6) |
Dead | 4 (19.0) | 1 ( 2.4) |
Tab 1 Basic information of 63 included patients
Characteristic | Metastasis group (n=21) | Non-metastasis group (n=42) |
---|---|---|
Gender/n(%) | ||
Female | 12 (57.1) | 22 (52.4) |
Male | 9 (42.9) | 20 (47.6) |
Race/n(%) | ||
Unknown | 9 (42.9) | 7 (16.7) |
Asian | 0 (0) | 1 (2.4) |
Black or African American | 2 (9.5) | 7 (16.7) |
White | 10 (47.6) | 27 (64.3) |
Survival status/n(%) | ||
Alive | 17 (81.0) | 41 (97.6) |
Dead | 4 (19.0) | 1 ( 2.4) |
DEG | Full name of gene | FDR | log2 FC |
---|---|---|---|
Up-regulated | |||
CA1 | Carbonic anhydrase 1 | 5.85×10-10 | 5.012 |
IGLJ2 | Immunoglobulin lambda joining 2 | 8.21×10-6 | 4.686 |
MS4A12 | Membrane spanning 4-domains A12 | 3.68×10-6 | 4.622 |
SST | Somatostatin | 9.04×10-7 | 4.547 |
GCG | Glucagon | 1.58×10-3 | 3.987 |
SLC26A3 | Solute carrier family 26 member 3 | 2.87×10-5 | 3.960 |
IGKV3OR2-5 | Immunoglobulin κ variable 3 or 2-5 (pseudogene) | 4.42×10-3 | 3.901 |
OGDHL | Oxoglutarate dehydrogenase l | 1.53×10-5 | 3.878 |
AQP8 | Aquaporin 8 | 4.66×10-4 | 3.828 |
HTR3C | 5-hydroxytryptamine receptor 3C | 6.22×10-3 | 3.813 |
Down-regulated | |||
GP2 | Glycoprotein 2 | 8.44×10-5 | -4.070 |
UICLM | Up-regulated in colorectal cancer liver metastasis | 3.59×10-2 | -3.663 |
FGL1 | Fibrinogen like 1 | 1.08×10-2 | -3.245 |
GPRC6A | G protein-coupled receptor class C group 6 member A | 1.91×10-2 | -3.231 |
DEFA6 | Defensin α 6 | 3.69×10-2 | -3.231 |
ACTL8 | Actin like 8 | 6.77×10-5 | -3.161 |
HSD3B1 | Hydroxy-δ-5-steroid dehydrogenase, 3 β- and steroid δ-isomerase 1 | 2.12×10-2 | -2.789 |
PADI3 | Peptidyl arginine deiminase 3 | 2.72×10-2 | -2.509 |
MRLN | Myoregulin | 3.02×10-2 | -2.477 |
SLC9A4 | Solute carrier family 9 member A4 | 2.03×10-2 | -2.344 |
Tab 2 Top 10 up-regulated and down-regulated DEGs between metastasis and non-metastasis group
DEG | Full name of gene | FDR | log2 FC |
---|---|---|---|
Up-regulated | |||
CA1 | Carbonic anhydrase 1 | 5.85×10-10 | 5.012 |
IGLJ2 | Immunoglobulin lambda joining 2 | 8.21×10-6 | 4.686 |
MS4A12 | Membrane spanning 4-domains A12 | 3.68×10-6 | 4.622 |
SST | Somatostatin | 9.04×10-7 | 4.547 |
GCG | Glucagon | 1.58×10-3 | 3.987 |
SLC26A3 | Solute carrier family 26 member 3 | 2.87×10-5 | 3.960 |
IGKV3OR2-5 | Immunoglobulin κ variable 3 or 2-5 (pseudogene) | 4.42×10-3 | 3.901 |
OGDHL | Oxoglutarate dehydrogenase l | 1.53×10-5 | 3.878 |
AQP8 | Aquaporin 8 | 4.66×10-4 | 3.828 |
HTR3C | 5-hydroxytryptamine receptor 3C | 6.22×10-3 | 3.813 |
Down-regulated | |||
GP2 | Glycoprotein 2 | 8.44×10-5 | -4.070 |
UICLM | Up-regulated in colorectal cancer liver metastasis | 3.59×10-2 | -3.663 |
FGL1 | Fibrinogen like 1 | 1.08×10-2 | -3.245 |
GPRC6A | G protein-coupled receptor class C group 6 member A | 1.91×10-2 | -3.231 |
DEFA6 | Defensin α 6 | 3.69×10-2 | -3.231 |
ACTL8 | Actin like 8 | 6.77×10-5 | -3.161 |
HSD3B1 | Hydroxy-δ-5-steroid dehydrogenase, 3 β- and steroid δ-isomerase 1 | 2.12×10-2 | -2.789 |
PADI3 | Peptidyl arginine deiminase 3 | 2.72×10-2 | -2.509 |
MRLN | Myoregulin | 3.02×10-2 | -2.477 |
SLC9A4 | Solute carrier family 9 member A4 | 2.03×10-2 | -2.344 |
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