JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (12): 1603-1611.doi: 10.3969/j.issn.1674-8115.2021.12.009
• Basic research • Previous Articles
Jian-xiao SHEN1(), Wan-peng WANG2, Xing-hua SHAO1, Jing-kui WU1, Shu LI1, Xia-jing CHE1, Zhao-hui NI1(
)
Received:
2021-08-12
Online:
2021-12-28
Published:
2022-01-28
Contact:
Zhao-hui NI
E-mail:shenjianxiao@aliyun.com;profnizh@126.com
Supported by:
CLC Number:
Jian-xiao SHEN, Wan-peng WANG, Xing-hua SHAO, Jing-kui WU, Shu LI, Xia-jing CHE, Zhao-hui NI. Changes of m6A methylation in renal tissue during cisplatin-induced acute injury[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(12): 1603-1611.
Gene name | Full name | Gene ID | Fold change | Regulation | Chromsome | Peak start | Peak end | Peak length | P value |
---|---|---|---|---|---|---|---|---|---|
BC061237 | cDNA sequence BC061237 | 385138 | 1 489.5 | Up | Chr14 | 44504106 | 44504291 | 185 | 0.000 |
BC061237 | cDNA sequence BC061237 | 385138 | 816.8 | Up | Chr14 | 44500121 | 44500197 | 76 | 0.000 |
Krt20 | Keratin 20 | 66809 | 498.7 | Up | Chr11 | 99430752 | 99430920 | 168 | 0.000 |
Krt20 | Keratin 20 | 66809 | 498.0 | Up | Chr11 | 99429021 | 99429078 | 57 | 0.000 |
Krt20 | Keratin 20 | 66809 | 483.5 | Up | Chr11 | 99432181 | 99432343 | 162 | 0.000 |
1700001F09Rik | RIKEN cDNA 1700001F09 gene | 71826 | 383.8 | Up | Chr14 | 43346701 | 43346790 | 89 | 0.000 |
Ccdc85b | Coiled-coil domain containing 85B | 240514 | 328.6 | Up | Chr19 | 5454141 | 5454580 | 439 | 0.000 |
Gm3543 | Predicted gene 3543 | 100041849 | 318.0 | Up | Chr14 | 41982201 | 41982290 | 89 | 0.000 |
Serpina3n | Serinepeptidase inhibitor, clade A, member 3N | 20716 | 316.3 | Up | Chr12 | 104414261 | 104414329 | 68 | 0.000 |
Gm3543 | Predicted gene 3543 | 100041849 | 254.0 | Up | Chr14 | 41982133 | 41982180 | 47 | 0.000 |
Alms1 | ALMS1 centrosome and basal body associated protein | 236266 | 503.6 | Down | Chr6 | 85694833 | 85694951 | 118 | 0.000 |
Tas2r119 | Taste Receptor, type 2, member 119 | 57254 | 385.6 | Down | Chr15 | 32177288 | 32177620 | 332 | 0.000 |
Ctnna2 | Catenin α 2 | 12386 | 220.8 | Down | Chr6 | 77600041 | 77600380 | 339 | 0.000 |
Afm | Afamin | 280662 | 195.1 | Down | Chr5 | 90518931 | 90519060 | 129 | 0.000 |
Slc5a4a | Solute carrier family 5, member 4a | 64452 | 126.7 | Down | Chr10 | 76163688 | 76163769 | 81 | 0.000 |
Nat1 | N-acetyltransferase 1 | 17960 | 123.5 | Down | Chr8 | 67490861 | 67491460 | 599 | 0.000 |
Pzp | PZP α-2-macroglobulin like | 11287 | 111.1 | Down | Chr6 | 128526621 | 128526720 | 99 | 0.000 |
Dpf3 | Double PHD fingers 3 | 70127 | 99.2 | Down | Chr12 | 83215461 | 83215800 | 339 | 0.000 |
Dgkg | Diacylglycerol Kinase γ | 110197 | 95.3 | Down | Chr16 | 22479365 | 22479426 | 61 | 0.000 |
Dpf3 | Double Phd fingers 3 | 70127 | 94.3 | Down | Chr12 | 83214541 | 83214840 | 299 | 0.000 |
Tab 1 Top 20 differentially methylated m6A peaks
Gene name | Full name | Gene ID | Fold change | Regulation | Chromsome | Peak start | Peak end | Peak length | P value |
---|---|---|---|---|---|---|---|---|---|
BC061237 | cDNA sequence BC061237 | 385138 | 1 489.5 | Up | Chr14 | 44504106 | 44504291 | 185 | 0.000 |
BC061237 | cDNA sequence BC061237 | 385138 | 816.8 | Up | Chr14 | 44500121 | 44500197 | 76 | 0.000 |
Krt20 | Keratin 20 | 66809 | 498.7 | Up | Chr11 | 99430752 | 99430920 | 168 | 0.000 |
Krt20 | Keratin 20 | 66809 | 498.0 | Up | Chr11 | 99429021 | 99429078 | 57 | 0.000 |
Krt20 | Keratin 20 | 66809 | 483.5 | Up | Chr11 | 99432181 | 99432343 | 162 | 0.000 |
1700001F09Rik | RIKEN cDNA 1700001F09 gene | 71826 | 383.8 | Up | Chr14 | 43346701 | 43346790 | 89 | 0.000 |
Ccdc85b | Coiled-coil domain containing 85B | 240514 | 328.6 | Up | Chr19 | 5454141 | 5454580 | 439 | 0.000 |
Gm3543 | Predicted gene 3543 | 100041849 | 318.0 | Up | Chr14 | 41982201 | 41982290 | 89 | 0.000 |
Serpina3n | Serinepeptidase inhibitor, clade A, member 3N | 20716 | 316.3 | Up | Chr12 | 104414261 | 104414329 | 68 | 0.000 |
Gm3543 | Predicted gene 3543 | 100041849 | 254.0 | Up | Chr14 | 41982133 | 41982180 | 47 | 0.000 |
Alms1 | ALMS1 centrosome and basal body associated protein | 236266 | 503.6 | Down | Chr6 | 85694833 | 85694951 | 118 | 0.000 |
Tas2r119 | Taste Receptor, type 2, member 119 | 57254 | 385.6 | Down | Chr15 | 32177288 | 32177620 | 332 | 0.000 |
Ctnna2 | Catenin α 2 | 12386 | 220.8 | Down | Chr6 | 77600041 | 77600380 | 339 | 0.000 |
Afm | Afamin | 280662 | 195.1 | Down | Chr5 | 90518931 | 90519060 | 129 | 0.000 |
Slc5a4a | Solute carrier family 5, member 4a | 64452 | 126.7 | Down | Chr10 | 76163688 | 76163769 | 81 | 0.000 |
Nat1 | N-acetyltransferase 1 | 17960 | 123.5 | Down | Chr8 | 67490861 | 67491460 | 599 | 0.000 |
Pzp | PZP α-2-macroglobulin like | 11287 | 111.1 | Down | Chr6 | 128526621 | 128526720 | 99 | 0.000 |
Dpf3 | Double PHD fingers 3 | 70127 | 99.2 | Down | Chr12 | 83215461 | 83215800 | 339 | 0.000 |
Dgkg | Diacylglycerol Kinase γ | 110197 | 95.3 | Down | Chr16 | 22479365 | 22479426 | 61 | 0.000 |
Dpf3 | Double Phd fingers 3 | 70127 | 94.3 | Down | Chr12 | 83214541 | 83214840 | 299 | 0.000 |
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