JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (12): 1613-1617.doi: 10.3969/j.issn.1674-8115.2021.12.010
• Basic research • Previous Articles
Rui LI1(), Duan ZENG1, Shen HE1, Yi-feng SHEN1, Hua-fang LI1,2,3()
Received:
2021-05-13
Online:
2021-12-28
Published:
2022-01-28
Contact:
Hua-fang LI
E-mail:18351998232@163.com;lhlh-5@163.com
Supported by:
CLC Number:
Rui LI, Duan ZENG, Shen HE, Yi-feng SHEN, Hua-fang LI. Association study of HRAS proto-oncogene single nucleotide polymorphism with schizophrenia and therapeutic response to atypical antipsychotics[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(12): 1613-1617.
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URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2021.12.010
Index | Responder group (n=132) | Non-responder group (n=323) | P value |
---|---|---|---|
Age/year | 48.19±17.26 | 48.75±13.11 | 0.741 |
Male/female/n | 63/69 | 155/168 | 0.960 |
Baseline PANSS score/score | 77.84±16.13 | 74.25±15.35 | 0.071 |
Onset age/year | 26.42±10.18 | 27.24±11.29 | 0.474 |
Disease course/year | 18 (5‒32) | 21 (8‒33) | 0.171 |
Drug dosage①/(mg·d-1) | 10.0 (5.0‒15.0) | 10.0 (5.0‒14.4) | 0.469 |
Baseline application of drug (users/non-users)/n | 97/35 | 217/106 | 0.187 |
Tab 1 Comparison of clinical features between the responder group and non-responder group
Index | Responder group (n=132) | Non-responder group (n=323) | P value |
---|---|---|---|
Age/year | 48.19±17.26 | 48.75±13.11 | 0.741 |
Male/female/n | 63/69 | 155/168 | 0.960 |
Baseline PANSS score/score | 77.84±16.13 | 74.25±15.35 | 0.071 |
Onset age/year | 26.42±10.18 | 27.24±11.29 | 0.474 |
Disease course/year | 18 (5‒32) | 21 (8‒33) | 0.171 |
Drug dosage①/(mg·d-1) | 10.0 (5.0‒15.0) | 10.0 (5.0‒14.4) | 0.469 |
Baseline application of drug (users/non-users)/n | 97/35 | 217/106 | 0.187 |
Group | Allele/n(%) | χ2 value | P value | Genotype/n(%) | χ2 value | P value | |||
---|---|---|---|---|---|---|---|---|---|
A | G | AA | AG | GG | |||||
Case group | 138 (15.2) | 772 (84.8) | 0.172 | 0.400 | 13 (2.9) | 112 (24.6) | 330 (72.5) | 1.008 | 0.600 |
Control group | 105 (13.7) | 661 (86.3) | 11 (2.9) | 83 (21.7) | 289 (75.5) | ||||
Responder group | 52 (19.7) | 212 (80.3) | 5.943 | 0.010 | 7 (5.3) | 38 (28.8) | 87 (65.9) | 6.332 | 0.040 |
Non-responder group | 86 (13.3) | 560 (86.7) | 6 (1.9) | 74 (22.9) | 243 (75.2) |
Tab 2 Comparison of allele and genotype frequencies between the case group and control group
Group | Allele/n(%) | χ2 value | P value | Genotype/n(%) | χ2 value | P value | |||
---|---|---|---|---|---|---|---|---|---|
A | G | AA | AG | GG | |||||
Case group | 138 (15.2) | 772 (84.8) | 0.172 | 0.400 | 13 (2.9) | 112 (24.6) | 330 (72.5) | 1.008 | 0.600 |
Control group | 105 (13.7) | 661 (86.3) | 11 (2.9) | 83 (21.7) | 289 (75.5) | ||||
Responder group | 52 (19.7) | 212 (80.3) | 5.943 | 0.010 | 7 (5.3) | 38 (28.8) | 87 (65.9) | 6.332 | 0.040 |
Non-responder group | 86 (13.3) | 560 (86.7) | 6 (1.9) | 74 (22.9) | 243 (75.2) |
Model | OR | 95%CI | P value |
---|---|---|---|
Codominant | 0.670 | ||
GG | 1.00 | ||
AG | 0.85 | 0.56‒1.28 | |
AA | 1.20 | 0.41‒3.47 | |
Dominant | 0.520 | ||
GG | 1.00 | ||
AG/AA | 0.88 | 0.59‒1.31 | |
Recessive | 0.680 | ||
GG/AG | 1.00 | ||
AA | 1.25 | 0.43‒3.61 | |
Log-additive | 0.93 | 0.66‒1.31 | 0.680 |
Tab 3 Correlation analysis between rs11246176 genotype and incidence risk in different genetic models
Model | OR | 95%CI | P value |
---|---|---|---|
Codominant | 0.670 | ||
GG | 1.00 | ||
AG | 0.85 | 0.56‒1.28 | |
AA | 1.20 | 0.41‒3.47 | |
Dominant | 0.520 | ||
GG | 1.00 | ||
AG/AA | 0.88 | 0.59‒1.31 | |
Recessive | 0.680 | ||
GG/AG | 1.00 | ||
AA | 1.25 | 0.43‒3.61 | |
Log-additive | 0.93 | 0.66‒1.31 | 0.680 |
Time | PANSS total score/score | Reduction rate of total score/% | PAA+AG/GG① | PAA/AG+GG② | ||||
---|---|---|---|---|---|---|---|---|
AA | AG | GG | AA | AG | GG | |||
Baseline | 73.08±10.00 | 76.47±11.71 | 75.08±13.28 | ‒ | ‒ | ‒ | ||
13 weeks | 57.46±13.75 | 58.38±15.48 | 55.15±15.56 | 37.01±23.94 | 35.39±40.17 | 31.06±41.33 | 0.293 | 0.672 |
26 weeks | 55.15±15.56 | 61.63±17.93 | 64.23±17.11 | 42.09±33.87 | 30.99±33.65 | 22.70±34.84 | 0.010 | 0.077 |
Tab 4 Comparison of PANSS total scores and reduction rates of total scores among different genotypes of rs11246176 (x±s)
Time | PANSS total score/score | Reduction rate of total score/% | PAA+AG/GG① | PAA/AG+GG② | ||||
---|---|---|---|---|---|---|---|---|
AA | AG | GG | AA | AG | GG | |||
Baseline | 73.08±10.00 | 76.47±11.71 | 75.08±13.28 | ‒ | ‒ | ‒ | ||
13 weeks | 57.46±13.75 | 58.38±15.48 | 55.15±15.56 | 37.01±23.94 | 35.39±40.17 | 31.06±41.33 | 0.293 | 0.672 |
26 weeks | 55.15±15.56 | 61.63±17.93 | 64.23±17.11 | 42.09±33.87 | 30.99±33.65 | 22.70±34.84 | 0.010 | 0.077 |
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