Baseline characteristics and lifestyle factors of single and co-morbidity of cardio-cerebrovascular diseases in Shanghai Community Elderly Cohort

doi:10.3969/j.issn.1674-8115.2022.03.004

Abstract

Abstract: Objective

·To explore the epidemiology and risk factors of single and co-morbidity of cardio-cerebrovascular diseases based on a large-scale prospective cohort of elderly people in the community.

Methods

·The subjects of the study came from Shanghai Community Elderly Cohort. The baseline survey of this cohort began in February 2019 and ended in August 2019, collecting information including demographic information, diseases and family history, lifestyle and psychological status of cohort members. According to self-reported coronary heart disease and/or stroke, all cohort members were divided into four groups, which were single coronary heart disease group, single stroke group, cardio-cerebrovascular disease group (with both coronary heart disease and stroke), and control group (without coronary heart disease and stroke). Baseline information, disease history, lifestyle factors, psychological and sleep status among the four groups were analysed.

Results

·A total of 17 948 eligible subjects participated in the cohort study, including 2 050 cohort members with single coronary heart disease, 724 cohort members with single stroke, 269 cohort members with cardio-cerebrovascular disease, and 14 905 cohort members without coronary heart disease and stroke. The average age of these four groups were (70.4±6.2) years, (71.8±7.1) years, (73.2±7.0) years and (68.3±5.9) years, respectively. The proportions of hypertension (76.6%), hyperlipidemia (38.3%) and diabetes (26.0%) were the highest in the cardio-cerebrovascular disease group, followed by the single stroke group (74.2%, 26.8% and 25.8%, respectively), and the single coronary heart disease group (72.9%, 21.1% and 21.7%, respectively), and the control group had the lowest proportion (54.6%, 8.7% and 15.4%, respectively). The proportions of depression symptoms (16.0%), anxiety symptoms (13.1%), sedentary habit (2.2%), and poor or fairly poor sleep (38.6%) in the cardio-cerebrovascular disease group were the highest, followed by the single stroke group (10.1%, 6.6%, 2.2% and 27.2%, respectively) and the single coronary heart disease group (7.9%, 4.8%, 0.5% and 27.0%, respectively). The proportion of regular exercise was the lowest in the cardio-cerebrovascular disease group (29.5%), while the proportion was the highest in the control group (39.2%).

Conclusion

·Patients with coronary heart disease or stroke, especially those with both coronary heart disease and stroke, have a high proportion of co-morbidity with primary diseases, unhealthy lifestyles and psychological disorders.

Key words: coronary heart disease, stroke, cohort, lifestyle

CLC Number:

R181.2

JIANG Huiru, LI Zheng, MA Zhuoran, WEI Lin, YUAN Ancai, HU Liuhua, CHEN Xiaoyu, GUO Yunyue, ZHANG Wei, PU Jun. Baseline characteristics and lifestyle factors of single and co-morbidity of cardio-cerebrovascular diseases in Shanghai Community Elderly Cohort[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(3): 282-289.

Figures/Tables 4

TrendMD

References 36

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Characteristic	Control group （n=14 905）	Single coronary heart disease group （n=2 050）	Single stroke group （n=724）	Cardio-cerebrovascular disease group （n=269）	F/χ² value	P value
Age/year	68.3±5.9	70.4±6.2^①	71.8±7.1^①②	73.2±7.0^①②③	181.8	0.000
Gender/n （%）					105.4	0.000
Male	7 088 （47.5）	755 （36.8）^①	339 （46.8）^②	86 （32.0）^①③
Female	7 817 （52.5）	1 295 （63.2）^①	385 （53.2）^②	183 （68.0）^①③

Characteristic	Control group （n=14 905）	Single coronary heart disease group （n=2 050）	Single stroke group （n=724）	Cardio-cerebrovascular disease group （n=269）	F/χ² value	P value
Age/year	68.3±5.9	70.4±6.2^①	71.8±7.1^①②	73.2±7.0^①②③	181.8	0.000
Gender/n （%）					105.4	0.000
Male	7 088 （47.5）	755 （36.8）^①	339 （46.8）^②	86 （32.0）^①③
Female	7 817 （52.5）	1 295 （63.2）^①	385 （53.2）^②	183 （68.0）^①③

Comorbidity	Control group （n=14 905）	Single coronary heart disease group （n=2 050）	Single stroke group （n=724）	Cardio-cerebrovascular disease group （n=269）	F value	P value
Hypertension/n （%）	8 136 （54.6）	1 494 （72.9）^①	537 （74.2）^①	206 （76.6）^①	372.6	0.000
Diabetes/n （%）	2 302 （15.4）	445 （21.7）^①	187 （25.8）^①	70 （26.0）^①	113.8	0.000
Hyperlipidemia/n （%）	1 295 （8.7）	432 （21.1）^①	194 （26.8）^①②	103 （38.3）^①④	666.9	0.000
Digestive system disease/n （%）	3 589 （24.1）	765 （37.3）^①	286 （39.5）^①	148 （55.0）^①③④	341.4	0.000
Respiratory system disease/n （%）	746 （5.0）	215 （10.5）^①	62 （8.6）^①	49 （18.2）^①③④	179.7	0.000
Malignant tumor/n （%）	396 （2.7）	59 （2.9）	27 （3.7）	8 （3.0）	3.3	0.350

Comorbidity	Control group （n=14 905）	Single coronary heart disease group （n=2 050）	Single stroke group （n=724）	Cardio-cerebrovascular disease group （n=269）	F value	P value
Hypertension/n （%）	8 136 （54.6）	1 494 （72.9）^①	537 （74.2）^①	206 （76.6）^①	372.6	0.000
Diabetes/n （%）	2 302 （15.4）	445 （21.7）^①	187 （25.8）^①	70 （26.0）^①	113.8	0.000
Hyperlipidemia/n （%）	1 295 （8.7）	432 （21.1）^①	194 （26.8）^①②	103 （38.3）^①④	666.9	0.000
Digestive system disease/n （%）	3 589 （24.1）	765 （37.3）^①	286 （39.5）^①	148 （55.0）^①③④	341.4	0.000
Respiratory system disease/n （%）	746 （5.0）	215 （10.5）^①	62 （8.6）^①	49 （18.2）^①③④	179.7	0.000
Malignant tumor/n （%）	396 （2.7）	59 （2.9）	27 （3.7）	8 （3.0）	3.3	0.350

Psychological status	Control group （n=14 905）	Single coronary heart disease group （n=2 050）	Single stroke group （n=724）	Cardio-cerebrovascular disease group （n=269）	F value	P value
Anxiety status/n （%）					249.9	0.000
No-anxiety symptom	14 600 （98.0）	1 952 （95.2）^①	676 （93.4）^①③	234 （87.0）^①③⑨
Mild-anxiety symptom	237 （1.6）	64 （3.1）^①	35 （4.8）^①④	23 （8.6）^①③⑩
Moderate-anxiety symptom	57 （0.4）	32 （1.6）^①	9 （1.2）^②	8 （3.0）^①
Severe-anxiety symptom	11 （0.1）	2 （0.1）	4 （0.6）^⑤	4 （1.5）^⑥
Depression status/n （%）					291.3	0.000
No-depressive symptom	14 406 （96.6）	1 888 （92.1）^①	651 （89.9）^①	226 （84.0）^①⑨
Mild-depressive symptom	410 （2.8）	123 （6.0）^①	53 （7.3）^①	29 （10.8）^①④⑦
Moderate-depressive symptom	88 （0.6）	37 （1.8）^①	18 （2.5）^②	12 （4.5）^①⑤⑧
Major-depressive symptom	1 （0.0）	2 （0.1）	2 （0.3）	2 （0.7）