Research progress in the role of Akkermansia muciniphila in gut-related diseases

doi:10.3969/j.issn.1674-8115.2022.10.016

Abstract

Abstract:

Akkermansia muciniphila (A. muciniphila) is one of the normal gut symbionts using mucin as the sole source of carbon and nitrogen elements to maintain colonization and growth. Intestinal homeostasis is crucial for maintaining physiological functions. Intestinal dysfunction is closely related to the occurrence and development of metabolic diseases, immune diseases, infectious diseases and tumors. Gut microbiota is a key factor that influences the intestinal health. As a member of the gut microbes, A. muciniphila plays a convincing role in intestinal inflammation, intestinal tumor and other intestinal disorders involving diseases such as liver diseases and metabolic diseases. The mechanism is under exploration and revealed gradually. Hence, A. muciniphila is considered to be a promising candidate of probiotics. The characteristics of A. muciniphila, its distribution in the gut, its relationship with gut-related diseases and the mechanism are reviewed.

Key words: Akkermansia muciniphila (A. muciniphila), inflammation, tumor, probiotics, gut microbiota

CLC Number:

R574.4

JIANG Yi, JIANG Ping, ZHANG Mingming, FANG Jingyuan. Research progress in the role of Akkermansia muciniphila in gut-related diseases[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(10): 1490-1497.

Figures/Tables 3

TrendMD

References 52

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Disease	Mouse model	Determinant	Effect （+/-）
Colitis	DSS induced colitis	Bacteria	-/+^{［17， 20］}
		AmEV	-^［18］
		Amuc_1100	-^［19］
Colitis	Salmonella typhimurium-infected colitis	Bacteria	+^［22］
Colitis	Il10^-/- mice spontaneous colitis	Bacteria	+^［23］
CAC	AOM/DSS induced CAC	Amuc_1100	-^［19］
CRC	Apc^Min/+ mice spontaneous CRC	Bacteria	-^［25］
CRC	HCT116/CT26 subcutaneously transplantation tumor	Bacteria	-^［25］
ALD	Alcohol induced ALD	Bacteria	-^［30］
Liver injury	ConA induced liver injury	Bacteria	-^［31］
Obesity/T2DM	High-fat diet induced obesity/T2DM	Bacteria	-^［33］
Obesity/T2DM	High-fat diet induced obesity/T2DM	Amuc_1100	-^［39］

Disease	Mouse model	Determinant	Effect （+/-）
Colitis	DSS induced colitis	Bacteria	-/+^{［17， 20］}
		AmEV	-^［18］
		Amuc_1100	-^［19］
Colitis	Salmonella typhimurium-infected colitis	Bacteria	+^［22］
Colitis	Il10^-/- mice spontaneous colitis	Bacteria	+^［23］
CAC	AOM/DSS induced CAC	Amuc_1100	-^［19］
CRC	Apc^Min/+ mice spontaneous CRC	Bacteria	-^［25］
CRC	HCT116/CT26 subcutaneously transplantation tumor	Bacteria	-^［25］
ALD	Alcohol induced ALD	Bacteria	-^［30］
Liver injury	ConA induced liver injury	Bacteria	-^［31］
Obesity/T2DM	High-fat diet induced obesity/T2DM	Bacteria	-^［33］
Obesity/T2DM	High-fat diet induced obesity/T2DM	Amuc_1100	-^［39］

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