›› 2010, Vol. 30 ›› Issue (2): 200-.

• Original article (Basic research) • Previous Articles     Next Articles

Changes in proliferative capability of remnant breast tumor after ablation with high intensity focused ultrasound

NIU Ling-chuan1, ZOU Wen-bing1, ZHANG Lian2, ZHU Hui2, XIANG Li-ke3, WANG Zhi-biao1,2   

  1. 1. Department of Biomedical Engineering, Chongqing University of Medical Sciences, Chongqing Key Laboratory of Ultrasound Medical Engineering, Chongqing 400016, China；2. Clinical Center for Tumor Therapy, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China；3. Department of Pathology, Chongqing University of Medical Sciences, Chongqing 400016, China
  • Online:2010-02-25 Published:2010-02-25

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Abstract:

Objective To observe the changes in proliferative capability of remnant tumors implanted in rabbit breast after ablation with high intensity focused ultrasound (HIFU). Methods Rabbit implanted models were established by implanting VX2 tumor mass into the breast of New Zealand rabbits. HIFU was applied to the tumors, and the remnant tumors were harvested by controlling temperature around probe of tumors. Fifty-six rabbits were randomly divided into control group(n=10) and HIFU group(n=40). The expression of proliferating cell nuclear antigen (PCNA) was detected by immunohistochemistry at different time points after ablation, and the survival time and organ metastasis status were observed after ablation. Results After ablation in HIFU group, the positive expression of PCNA was decreased shortly in remnant tumors, and restored to the level before ablation 21 days after treatment. The survival time in HIFU group was much longer than that in control group, and the time of lung and abdominal viscera metastasis in HIFU group appeared significantly later than that in control group (P＜0.05). Conclusion Though HIFU ablation can not completely eradicate tumor after one treatment, the growth and metastasis of remnant tumors can be effectively inhibited for a short time, and HIFU ablation can prolong the survival time.

Key words: high intensity focused ultrasound, tumor, ablation, proliferating cell nuclear antigen, breast cancer