›› 2010, Vol. 30 ›› Issue (9): 1138-.doi: 10.3969/j.issn.1674-8115.2010.09.028

• Original article (Clinical research) • Previous Articles     Next Articles

Expression of Survivin, Fas and FasL in cervical cancer and their relationship

WU Su-fang, ZHANG Jia-wen, QIU Min, YANG Yong-bin, FENG You-ji   

  1. Department of Obstetrics and Gynecology, The First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2010-09-25 Published:2010-09-27
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 09411962500；Shanghai Municipal Health Bureau Foundation, 054019；Foundation from The First People's Hospital, Shanghai Jiaotong University, 06B27

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Abstract:

Objective To investigate the expression of Survivin, Fas and FasL in tissues of different cervical lesions, and analyse the relationship between the expression of Survivin and that of Fas/FasL in tissues of cervical cancer. Methods The expression of Survivin, Fas and FasL in tissues of 47 cases of cervical cancer, 25 cases of cervical intraepithelial neoplasia (CIN), 20 cases of chronic cervicitis and 20 cases of normal cervix was detected by immunohistochemical staining (SP method), and the relationship between the expression of Survivin, Fas and FasL and clinical pathologic characteristics of cervical cancer was analysed. Besides, the relationship between the expression of Survivin and that of Fas/FasL in tissues of cervical cancer was explored by Spearman rank correlation analysis. Results The positive expression rate of Survivin was 68.1% in tissues of cervical cancer, which was significantly higher than those in tissues of normal cervix (0%), chronic cervicitis (15.0%) and CIN (36.0%) (P<0.05). The positive expression rate of Fas was 48.9% in tissues of cervical cancer, which was significantly lower than those in tissues of normal cervix (90.0%), chronic cervicitis (85.0%) and CIN (80.0%) (P<0.05). The positive expression rate of FasL was 93.6% in tissues of cervical cancer, which was significantly higher than those in tissues of normal cervix （0%）, chronic cervicitis (50.0%) and CIN （68.0%）(P<0.05). The expression of Survivin was correlated with clinical staging and lymphnode metastases of cervical cancer （P<0.05）. The expression of FasL was correlated with lymphnode metastases, clinical staging and pathological grading of cervical cancer （P<0.05）. The expression of Survivin was negatively correlated with that of Fas in tissues of cervical cancer (r=-0.517，P<0.01), and was positively correlated with that of FasL (r=0.381，P<0.01). Conclusion The up-regulation of expression of Survivin and FasL and down-regulation of expression of Fas may take part in the carcinogenesis and development of cervical cancer, which may be the mechanism by which tumor cells evade the immune surveillance. The expression of FasL may be one of the prediction indexes for disease progression and prognosis in cervical cancer.

Key words: cervical cancer, immunohistochemistry, Survivin, Fas, FasL, apoptosis