Abstract:

There is a high incidence of prostate cancer in western countries, and there has been an increasing incidence in China. Early detection of prostate cancer is the key to management and prognosis. There exist limitations in non-invasive diagnostic approaches for prostate cancer. TMPRSS2-ETS fusion gene is a novel biomarker proved to have correlation with prostate cancer, and TMPRSS2-ERG fusion is the most common subtype of ETS fusions. Urinary detection of TMPRSS2-ETS fusion gene has a definite value in the early diagnosis of prostate cancer, with higher specificity and positive predictive value. The research progress and clinical implication prospect of TMPRSS2-ETS gene fusion in prostate cancer are reviewed in this paper.

Key words: prostate cancer, TMPRSS2, ETS, ERG, ETV1, ETV4, fusion gene