›› 2011, Vol. 31 ›› Issue (8): 1129-.doi: 10.3969/j.issn.1674-8115.2011.08.019

• Original article (Clinical research) • Previous Articles     Next Articles

Expression of tumor-associated antigen OVA66 in human tumor tissues

RONG Ting-ting1, RAO Wei1, CHEN Hui-juan1, WANG Ying1, ZHANG Yong1, SHEN Li-song2, GE Hai-liang1   

  1. 1.Department of Immunology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China；2.Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-08-28 Published:2011-08-29
  • Supported by:

    National Natural Science Foundation of China,30972786；Shanghai Science and Technology Committee Foundation,10411950400；Shanghai Leading Academic Discipline Project, JS0207

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Abstract:

Objective To investigate the expression of tumor-associated antigen OVA66 in human tumor tissues, and explore its clinical values. Methods Immunohistochemistry was employed to detect the expression of OVA66 protein in several types of tumor tissue chips and samples (gastric cancer, intestinal cancer, lung cancer, breast cancer, ovarian cancer, bladder cancer and renal cancer) and corresponding non-tumor tissues. The relationship between the expression of OVA66 protein and character of tumor tissues, tumor metastasis and clinicopathological characteristics was analysed. Results There was high expression of OVA66 protein in the tumor tissues of stomach, intestine, ovary, bladder and kidney, which was significantly higher than that in non-tumor tissues. While the expression of OVA66 was relatively lower in the tumor tissues of lung and breast. The expression of OVA66 in bladder cancer tissues was related to the pathological grading of bladder cancer. The expression of OVA66 in intestinal cancer and bladder cancer with lymph node metastasis was slightly higher than that in intestinal cancer and bladder cancer without lymph node metastasis, while there was no significant difference between them. Conclusion There is high expression of OVA66 protein in many tumor tissues. The expression of OVA66 protein in bladder cancer tissues is related to the pathological grading of bladder cancer. OVA66 may serve as a novel tumor marker in the diagnosis of tumors.

Key words: OVA66, tissue microarray, immunohistochemistry