›› 2011, Vol. 31 ›› Issue (12): 1707-.doi: 10.3969/j.issn.1674-8115.2011.12.010

• Original article (Basic research) • Previous Articles     Next Articles

Effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats

SHEN Li1, YIN Jun2, ZHOU Jun3   

  1. 1.Department of Clinical Nutrition, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;2.Department of Endocrinology and Metabolism, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;3.Laboratory of Endocrinology and Metabolism, Veterans Affairs Medical Center, Washington DC 20422, USA
  • Online:2011-12-28 Published:2012-01-04

Abstract:

Objective To investigate the effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats. Methods Twenty female Goto-Kakizaki (GK) rats with type 2 diabetes aged 6 weeks were randomized into resistant starch diet group (GK-RS group, n=10) and energy control diet group (GK-EC group, n=10), and another 10 age-matched female Wistar rats fed with energy control diet were served as blank control group (Wistar-EC group). Ten male offsprings were randomly selected in each group, and were raised till 8 weeks old on regular chow diet. Body weight and volume of food intake were recorded three time a week, pancreatic relative β cell density was measured by immunohistochemistry, fasting serum insulin concentration was detected by ELISA, concentrations of fasting blood glucose and 2 h postprandial blood glucose were determined by oral glucose tolerance test, and insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Results Compared with GK-EC group, the concentration of fasting blood glucose significantly decreased (P<0.05), pancreatic insulin content significantly increased (P<0.05), and pancreatic relative β cell density tended to increase in GK-RS group (P=0.07). There was no significant difference in body weight, volume of food intake, HOMA-IR and concentrations of 2 h postprandial blood glucose and fasting serum insulin between GK-EC group and GK-RS group (P>0.05). Conclusion Dietary resistant starch has potential in improving glucose metabolism disorder in offsprings born to diabetic dams.

Key words: resistant starch, type 2 diabetes, glucose metabolism, offspring