Telomeres, mitochondria and stem cell aging

doi:10.3969/j.issn.1674-8115.2012.05.033

›› 2012, Vol. 32 ›› Issue (5): 679-.doi: 10.3969/j.issn.1674-8115.2012.05.033

• Review • Previous Articles Next Articles

Telomeres, mitochondria and stem cell aging

HUANG Li-ya, CHEN Shu-yan

Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Online:2012-05-28 Published:2012-06-01

Abstract

Abstract:

Stem cells are the special cells which play a key role in the whole life cycle. It is very important to maintain the activity of stem cells, slow down stem cell aging and prolong the life of stem cells. In this paper, the molecular mechanism of stem cell aging is reviewed from the aspects including genome maintenance, telomeres, cell cycle inhibitors and mitochondria. The relationship between telomere-p53 pathway and mitochondria-reactive oxygen species pathway is focused, and the impacts of the two pathways on stem cell aging are introduced.

Key words: stem cell, aging, telomere, p53, mitochondria, reactive oxygen species

HUANG Li-ya, CHEN Shu-yan. Telomeres, mitochondria and stem cell aging[J]. , 2012,(5): 679-.

[1]	Wu Jialong, Chen Xuzhuo, Huang Enkui, Yin Xiuyuan, Xu Qianhe, Liu Peinian, Zhang Shanyong. Anti-inflammatory and antioxidant effects of tannic acid-based ROS-responsive hydrogel in macrophage inflammation [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(7): 886-895.
[2]	Ding Xinyi, Zhu Yi, Wang Jingyi, Deng Jiali, Wang Zhongling. 4T1 cell membrane-biomimetic nanoprobe based on glutathione depletion for inducing tumor ferroptosis and MR imaging [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(7): 906-915.
[3]	Zhang Yue, Xia Yiqiu, He Xiaoxiao, Chen Chiqi, Zhang Yaping, Wang Yu, Zheng Junke, Xie Li, Yu Zhuo. Adenosine monophosphate deaminase 3 regulates the bone marrow reconstitution ability of hematopoietic stem cells through the CREB/ADCY10 signaling pathway [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(6): 693-704.
[4]	Deng Yincan, Chen Jing, Wang Linying, Guo Xuejing, Qian Xubo, Zhu Dan. Value of T-cell mitochondrial damage index in predicting the risk of acute exacerbation of chronic obstructive pulmonary disease [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(5): 633-641.
[5]	Chen Jiayu, Zhang Huili. Role and mechanism of fibroblast mitochondrial dysfunction in pulmonary arterial hypertension [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(3): 291-300.
[6]	Wang Guanzhen, He Wenrui, Tong Xuemei. Mechanisms and therapeutic applications of transketolase in regulating pentose phosphate metabolism and mitochondrial function [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(2): 137-142.
[7]	Wu Di, Ma Jun. Research progress on mitochondrial pathological mechanisms and targeted therapy in children with autism spectrum disorder [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(1): 115-122.
[8]	WANG Jingyi, DENG Jiali, ZHU Yi, DING Xinyi, GUO Jiajing, WANG Zhongling. Experimental study on novel pH-responsive manganese-based nanoprobes for ferroptosis and magnetic resonance imaging in breast cancer [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(9): 1183-1193.
[9]	LI Siyu, CHEN Ya, HU Wentao, DAI Yongming, WU Yingwei. Using diffusion-relaxation correlation spectroscopic imaging to assess the heterogeneity of head and neck tumors and identify occult lymph node metastasis [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(9): 1202-1213.
[10]	WANG Rui, YUAN Ying, TAO Xiaofeng. Application value of synthetic magnetic resonance imaging in predicting cervical lymph node metastasis of oral cancer [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(7): 900-909.
[11]	KERANMU Saitierguli, QIAN Lei, DING Siyi, MAHELIMUHAN Hanati, YANG Xueer, JIA Hao. Research progress of arginine metabolism in the regulation of mesenchymal stem cell function [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(7): 910-915.
[12]	SUN Lei, DAI Shifeng, CHEN Yuhua, XU Xinyi, JIANG Kele, LI Xiaowen, LI Chengjing, WU Tingting. Quantitative analysis of the distance between articular disc and condyle in patients with temporomandibular disorders [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(6): 684-692.
[13]	LI Zhuohang, YU Xindi, REN Jingya, SHEN Jia, DONG Suzhen, WANG Wei. Postoperative neurodevelopmental outcomes of end-to-side anastomosis for coarctation of the aorta [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(6): 753-759.
[14]	GU Liangrui, YAN Bicong, FANG Tonglei, WU Jinliang. Correlation between brain imaging features and cognitive impairment in end-stage renal disease patients based on susceptibility-weighted imaging [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(6): 760-765.
[15]	ZHANG Zhengjia, LI Xiaomin, ZHOU Xin, MA Hairong, AI Songtao. Preliminary study on the value of high-order functional magnetic resonance imaging in the evaluation of bone and soft tissue tumors [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(5): 585-596.

Telomeres, mitochondria and stem cell aging

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

TrendMD

References

Related Articles 15

Recommended Articles

Metrics

Comments