Telomeres, mitochondria and stem cell aging

doi:10.3969/j.issn.1674-8115.2012.05.033

›› 2012, Vol. 32 ›› Issue (5): 679-.doi: 10.3969/j.issn.1674-8115.2012.05.033

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Telomeres, mitochondria and stem cell aging

HUANG Li-ya, CHEN Shu-yan

Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Online:2012-05-28 Published:2012-06-01

Abstract

Abstract:

Stem cells are the special cells which play a key role in the whole life cycle. It is very important to maintain the activity of stem cells, slow down stem cell aging and prolong the life of stem cells. In this paper, the molecular mechanism of stem cell aging is reviewed from the aspects including genome maintenance, telomeres, cell cycle inhibitors and mitochondria. The relationship between telomere-p53 pathway and mitochondria-reactive oxygen species pathway is focused, and the impacts of the two pathways on stem cell aging are introduced.

Key words: stem cell, aging, telomere, p53, mitochondria, reactive oxygen species

HUANG Li-ya, CHEN Shu-yan. Telomeres, mitochondria and stem cell aging[J]. , 2012, 32(5): 679-.

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Telomeres, mitochondria and stem cell aging

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