Abstract:

Objective To evaluate the effectiveness of dezocine combined with propofol in anesthesia for painless gastroscopy in elderly patients. Methods One hundred and forty-seven elderly patients undergoing painless gastroscopy were randomly assigned to dezocine group (D group, n=51, infusion with dezocine 20 μg/kg + infusion with propoful 1 mg/kg 5 min later), sufentanil group (S group, n=46, infusion with sufentanil 0.1 μg/kg+ infusion with propoful 1 mg/kg 5 min later) and control group (C group, n=50, infusion with normal saline+ infusion with propoful 1 mg/kg 5 min later). The mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR) and pulse oxygen saturation (SpO2) were obtained before infusion (T1), after disappearance of eyelash reflex (T2) and after recovery of orientation (T3), and the adverse events, time for regaining consciousness and propofol dosage were also recorded. Results MAP at the time point of T2 was significantly lower than that at the time point of T1 in each group (P＜0.05), and the decrease was alleviated in D group compared with C group and S group (P＜0.05). HR was significantly decreased in C group and D group at the time point of T2, and the decrease in D group was more significant than that in C group (P＜0.05). RR and SpO2 were significantly decreased in C group at the time point of T2, and SpO2 in C group was significantly lower than that in S group and D group at the time point of T2 (P＜0.05). Time for regaining consciousness and propofol dosage in S group and D group were significantly lower than those in C group (P＜0.05), and there were significant differences between D group and S group (P＜0.05). Conclusion The application of dezocine combined with propofol in anesthesia for painless gastroscopy in elderly patients may significantly reduce the dosage of propofol, stabilize the respiratory and circulatory function, and have favorable safety.

Key words: dezocine, elderly, painless gastroscopy