Abstract:

Parkinson´s disease (PD) is one of the most common neurodegenerative diseases, Because of high prevalence, severe disability and chronic course of disease, it becomes one of research focus in modern medicine from diagnosis to treatment and prevention. Based on our previous studies, we further extended our investigation into the field of pathogenesis, diagnosis and treatment in PD with characteristics of translational medicine. We found that: ①Serum IgG and C5a from PD patients could activate the microglia and produce the damage effects in turn; and lysosome enzyme released by early microglia activation was harmful for the dopaminergic neurons; ②Three kinds of traditional Chinese herbal medicine—curcumin, salidroside and tripchlorolide (TW397) had neuroprotective and therapeutic effects in cellular and animal models of PD; ③Two types of neuron stem cells (c17.2 neuron stem cell transfected with neurturin or IL-10, or bone marrow stem cell transfected with neurturin) were proved exerting neuroprotective and therapeutic effects in rat models of PD; ④We investigated the economic burden of PD in China and provided the first data of the current pharmacoeconomics situation in Chinese PD patients. Furthermore, we presided the first and second version “Chinese guidelines for the treatment of Parkinson´s disease”, which intended to standardize the clinical treatment of PD in China. The research achievement won the first prize of Natural Science Award of Ministry of Education in 2010.

Key words: Parkinson´s disease, microglia, neuroprotect, diagnosis, treatment