Most Down Articles

Published in last 1 year | In last 2 years| In last 3 years| All| Most Downloaded in Recent Month| Most Downloaded in Recent Year|

Most Downloaded in Recent Month

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Advances in resilience research Shuang-yi CHEN, Jian-yin QIU JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (10): 1397-1400.   DOI: 10.3969/j.issn.1674-8115.2021.10.021 Abstract （1003）   HTML （40）    PDF（pc） （773KB）（1191）       Knowledge map    Save Resilience refers to the dynamic process of individual's positive adaptation to adversity, which is closely related to the symptoms of mental disorders and can be improved through intervention. This paper reviews the definition, evaluation method and intervention of resilience, and proposes that resilience can be used as an indicator of mental disorders related to stressor exposure, which has certain reference significance for improving individual resilience and promoting individual mental health development. Reference | Related Articles | Metrics

Select

Protocols for diagnosis and treatment of temporomandibular joint osteoarthritis: experience from the TMJ Center of Shanghai Ninth People 's Hospital, Shanghai Jiao Tong University School of Medicine ZHANG Shanyong, YANG Chi Journal of Shanghai Jiao Tong University (Medical Science)    2022, 42 (6): 709-716.   DOI: 10.3969/j.issn.1674-8115.2022.06.003 Abstract （998）   HTML （22）    PDF（pc） （1625KB）（864）       Knowledge map    Save Temporomandibular joint osteoarthritis (TMJOA) is the most common degenerative disease in the temporomandibular joint, mainly manifesting with pain in the joints and the muscles, joint locking, popping, crepitus, and limited mouth opening, which may undermine the quality of patients' life. The main pathological features of TMJOA include chronic synovitis, progressive articular cartilage degeneration, and abnormal subchondral bone remodeling. At present, its pathogenesis is still unclear, and abnormal mechanical load, trauma, heredity, metabolism, gender and age can all be regarded as pathogenic factors. Commonly used diagnostic methods for TMJOA include magnetic resonance imaging (MRI) and computed tomography [(CT/cone beam CT (CBCT)]. The staging standards of TMJOA mainly include Wilkes staging system and Yang's staging system. The clinical treatment of TMJOA mainly includes two categories: non-surgical treatment and surgical treatment. Non-surgical treatment includes health education, psychological consultation, medication, occlusion treatment, etc. Surgical treatment includes arthrocentesis, arthroscopic surgery, disc anchoring, autogenous tissue graft, and total joint replacement. This paper summarizes the diagnosis, staging, surgical treatment and postoperative evaluation of TMJOA on the basis of literature review, and proposes diagnosis and treatment protocols based on the experience of the TMJ Center of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, so as to provide reference for clinicians. Table and Figures | Reference | Related Articles | Metrics

Select

Progress in metabolism of the immune cells in tumor microenvironment LIN Jiayu, QIN Jiejie, JIANG Lingxi Journal of Shanghai Jiao Tong University (Medical Science)    2022, 42 (8): 1122-1130.   DOI: 10.3969/j.issn.1674-8115.2022.08.018 Abstract （681）   HTML （49）    PDF（pc） （2370KB）（727）       Knowledge map    Save Metabolic reprogramming refers to cells' mechanism to change their metabolic patterns in order to meet the increased energy demand caused by growth and proliferation. By way of metabolic reprogramming such as the Warburg effect, tumor cells gain rich energy to support their own survival, growth, and metastasis. The tumor microenvironment (TME) is the internal environment in which tumor cells survive, containing not only tumor cells, but also stromal cells, immune cells, and other components that are closely related to tumor cells. Meanwhile, tumor cells regulate intercellular function and signaling via secreting cytokines, metabolites, and other molecules and shape a commonly hypoxic, acidic, and nutrient-deprived TME which contributes the most to immune resistance. However, rapidly proliferating tumor cells compete for relatively scarce nutrients with immune cells, consequently, producing an immunosuppressive metabolism microenvironment. Under the influence of immunosuppressive TME, immune cells generate tolerance phenotype-related metabolic adaptations through metabolic reprogramming to satisfy their own needs and further perform anti-tumor or immunosuppressive roles. The response of immune cells to tumor cells mainly depends on respective unique metabolic pathways, which are related to the type and function of immune cells. Moreover, the functional properties of immune cells are directly associated with the immunotherapy effects. Regulating metabolic pathways of immune cells provides a great direction for cancer therapy. In this paper, the main metabolic pathways of immune cells in TME is described, the relationship between their metabolic characteristics and immune functions is summarized, and the mechanism of metabolic pathways underlying the functions of immune cells is further discussed, providing new insights for unveiling tumor immunosuppressive microenvironment and improving the efficacy of tumor immunotherapy. Table and Figures | Reference | Related Articles | Metrics

Select

Review of clinical application of peripheral neuropathy scales Qun-feng WANG, Li CAO, Xing-hua LUAN JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (11): 1518-1523.   DOI: 10.3969/j.issn.1674-8115.2021.11.018 Abstract （897）   HTML （90）    PDF（pc） （867KB）（1158）       Knowledge map    Save Peripheral neuropathy (PN) refers to a group of diseases caused by the dysfunction and structural changes of peripheral motor, sensory and autonomic nerves. Scales for screening and assessing PN are continuously being used in clinical practice. This article summarizes PN score scales for four kinds of PN, including chronic inflammatory demyelinating polyradiculoneuropathy, Charcot-Marie-Tooth disease, diabetic PN and neuropathic pain, aiming to improve medical staff's understanding and application ability of the PN assessment scale. Table and Figures | Reference | Related Articles | Metrics

Select

Diagnosis and treatment protocol of mandibular condylar fracture: experience from the TMJ Center of Shanghai Ninth People 's Hospital, Shanghai Jiao Tong University School of Medicine HE Dongmei, YANG Chi Journal of Shanghai Jiao Tong University (Medical Science)    2022, 42 (6): 695-701.   DOI: 10.3969/j.issn.1674-8115.2022.06.001 Abstract （817）   HTML （34）    PDF（pc） （2911KB）（488）       Knowledge map    Save Mandibular condylar fracture is common in clinic. Improper treatment will cause sequelae such as malocclusion, ankylosis and limited mandibular development. This paper combines the literature review and the diagnosis and treatment experience of the team to provide reference for clinicians. Imaging diagnosis, especially coronal CT reconstruction, is the basis for classification and treatment of condylar fracture. According to the fracture location, it is divided into condylar (intracapsular) fracture, condylar neck fracture and subcondylar fracture. And intracapsular fracture can be further divided into four types: A, B, C and M. The treatment of condylar fracture includes non-surgical treatment and surgical treatment. For non-surgical treatment, intermaxillary elastic traction is recommended for malocclusion correction. The absolute indication of surgical treatment is the ramus stump dislocated out of the fossa. The relative indications include the stump of the mandibular ramus contacting the articular fossa, severe displacement or dislocation of the condylar neck and subcondylar fracture. The key points of successful operation include adequate exposure, anatomic reduction and stable fixation, protection of lateral pterygoid muscle attachment and articular cartilage, and reposition of the temporomandibular joint disc. For the condylar fracture combined with mandibular fracture, lingual fissure of the mandible should be closed during reduction and fixation for restoring the mandibular width and condylar position in the fossa. When the condylar fracture is combined with midface fracture, the condylar fracture and occlusal relationship should be restored first, and then the maxillary fracture should be fixed according to the lower dentition. The children under 6 years old have the stronge ability of condylar remodeling, so non-surgical treatment is commonly used. The healing and remodeling ability of condyle gradually decreases with age. The condyles of the teenagers over 12 years old are close to those of the adults, so the indications of surgical treatment for condyle fracture refer to the adults. Table and Figures | Reference | Related Articles | Metrics

Select

Application and research progress of tetrahedral framework nucleic acids in the field of medicine XIE Shasha, LÜ Yehui, LIN Jian Journal of Shanghai Jiao Tong University (Medical Science)    2023, 43 (3): 380-384.   DOI: 10.3969/j.issn.1674-8115.2023.03.015 Abstract （412）   HTML （36）    PDF（pc） （1502KB）（353）       Knowledge map    Save Since the first proposal by Seeman in 1982, DNA nanostructures have been gradually improved, and have been widely developed and applied to the field of biomedical fields. In recent years, as a representative of 3D DNA nanostructures, tetrahedral framework nucleic acids (tFNA) has made certain research progress and has good application prospects in frontier fields such as biosensors, tumor therapy, antigen detection, regenerative medicine, with the advantages of their good biocompatibility, editability, high stability and easy preparation. This paper briefly describes the concepts of tFNA, and summarizes the applications and research progress of tFNA in the following fields from the perspective of therapeutic applications: ① Building novel self-assembled complexes to improve the efficacy of free drugs, carrying small RNA molecules to slow down tumor progression, and self-assembled complexes for targeted therapy, etc, as biological vectors and tumor drug delivery. ② Regulating inflammation and immune response, such as reducing the level of inflammatory factors, treating inflammatory diseases, preventing diabetes, and acting as immunomodulators, etc. ③ Enhancing tissue regeneration, such as promoting stem cell proliferation and differentiation, stimulating peripheral nerve regeneration, and facilitating wound repair through angiogenesis. This review summarizes the research progress of tFNA, and looks forward to its application prospects based on the analysis of the shortcomings of existing research, in order to provide reference for further research. Table and Figures | Reference | Related Articles | Metrics

Select

Research progress in health risk assessment of perfluorinated compounds among Chinese population Qian YAO, Ying TIAN JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (6): 803-808.   DOI: 10.3969/j.issn.1674-8115.2021.06.017 Abstract （1488）   HTML （76）    PDF（pc） （1159KB）（1116）       Knowledge map    Save Perfluorinated compounds (PFAS) are a new class of persistent organic pollutants that have attracted wide attention in recent years. With the increasing restrictions on PFAS in Europe and the United States, the production of PFAS is gradually transferring to China. The amount of PFAS used in China is increasing year by year, but there are no strict restrictions on the use of them. Furthermore, the safety limits are heading down in Europe and the United States. Based on the updated safety limits, studies in Chinese population have gradually indicated the potential risk of PFAS. This review summarizes the updated international safety limits, and introduces the research progress in health risk assessment of PFAS exposure in Chinese population according to different sources of exposure (diet, milk, drinking water, dust, atmosphere, placental transfer and comprehensive sources). The existing studies mainly focus on the health risk of PFAS exposure in high PFAS-polluted areas and in sensitive infant population in China, while the health risk of PFAS exposure in general population still needs to be further evaluated. It is necessary to carry out relevant work, which can provide reference for relevant government departments to formulate PFAS control standards and safety limits in line with China's national conditions as soon as possible. In addition, the future assessment research should pay more attention to complex evaluation of various sources of PFAS and the health hazards of PFAS alternatives. Reference | Related Articles | Metrics

Select

Research progress in animal model of acute lung injury Jing-yi FU, Lei WANG, Yi YANG JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (5): 690-694.   DOI: 10.3969/j.issn.1674-8115.2021.05.022 Abstract （1087）   HTML （61）    PDF（pc） （1153KB）（828）       Knowledge map    Save Acute lung injury (ALI) refers to the occurrence of hypoxic respiratory failure and even acute respiratory distress syndrome caused by various factors. The morbidity and fatality rate of ALI are very high, but the research on its pathogenesis and treatment methods has not made much progress. Therefore, it is very necessary to establish animal models to simulate acute lung injury. In this paper, the literature on animal models of ALI in recent years is collected and summarized, and the selection of animal models of acute lung injury and the evaluation methods of lung injury are reviewed, so as to provide reference for the establishment of animal models of ALI. Reference | Related Articles | Metrics

Select

Research progress and development trend of lower extremity exoskeleton rehabilitation robot Jiyu HAN, Yanhong WANG, Daqian WAN JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2022, 42 (2): 241-246.   DOI: 10.3969/j.issn.1674-8115.2022.02.017 Abstract （1769）   HTML （469）    PDF（pc） （917KB）（1536）       Knowledge map    Save Lower limb motor dysfunction caused by various causes is an important public health problem in the world today. Lower extremity exoskeleton rehabilitation robot is a new type of wearable bionic device, which is mainly used to realize the standing and walking of patients with lower extremity motor dysfunction. It is a hot research topic in rehabilitation medicine at present. By reviewing the history of lower extremity exoskeleton rehabilitation robot, some breakthroughs and developments are found to have been made in this field in recent years. In the future, if we can overcome the technical problems such as portability, intelligence and modularization, it will be possible to maximize the recovery of patients with lower limb dysfunction. In this paper, the key technologies and clinical applications of wearable lower extremity exoskeleton rehabilitation robot are reviewed comprehensively, and new prospects for the research and development in this field are proposed. Reference | Related Articles | Metrics

Select

Research progress in the role and mechanism of lactylation in diseases GE Lingling, HUANG Hongjun, LUO Yan Journal of Shanghai Jiao Tong University (Medical Science)    2023, 43 (3): 374-379.   DOI: 10.3969/j.issn.1674-8115.2023.03.014 Abstract （871）   HTML （58）    PDF（pc） （1230KB）（778）       Knowledge map    Save Lactic acid is a product of cell respiration. After entering into cells, glucose is metabolized to pyruvate by glycolysis. When the oxygen supply is sufficient, pyruvate is converted to acetyl coenzyme A through pyruvate dehydrogenase in the mitochondrial matrix to participate in the tricarboxylic acid cycle and provide necessary energy for cells. Pyruvate is catalysed by lactate dehydrogenase in the cytoplasm to produce lactate while cells are grown under hypoxic conditions. Lactate not only provides energy for mitochondrial respiration, but also plays important roles in inflammatory responser, wound repair, memory formation and neuroprotection as well as tumor growth and metastasis and other pathophysiological processes through autocrine, paracrine, and endocrine forms, which affects the development and prognosis of diseases. Epigenetic modification regulates gene replication, transcription and translation by covalently adding or hydrolyzing functional groups on histones and DNA through related enzymes and affects the biological effects of cells. Histones are the major structural proteins of eukaryotic chromosomes. Their post-translational modifications, such as methylation and acetylation, affect their affinity with DNA, change chromatin structures, and are widely involved in regulation of gene expression. Recent studies have found that histones can undergo lactylation, which is a new epigenetic modification by adding lactate to lysine residues on histones. As the research deepens, numerous evidences reveal that lactylation also occurs on non-histone proteins. The discovery of lactylation has expanded our understanding of lactate functions in the pathogenesis of diseases. In this review, we summarize the roles and mechanisms of lactylation in tumor, inflammatory and neural system diseases, in order to provide new ideas for the research, diagnosis and treatment of these diseases. Reference | Related Articles | Metrics

Select

Exploration of the relationship between nicotinamide metabolism-related genes and osteoarthritis DENG Qingsong, ZHANG Changqing, TAO Shicong Journal of Shanghai Jiao Tong University (Medical Science)    2024, 44 (2): 145-160.   DOI: 10.3969/j.issn.1674-8115.2024.02.001 Abstract （137）   HTML （23）    PDF（pc） （5348KB）（121）       Knowledge map    Save Objective ·To explore the relationship between osteoarthritis and nicotinamide metabolism-related genes using bioinformatics analysis, and identify key genes with diagnostic value and therapeutic potential. Methods ·By using "Osteoarthritis" as a search term, GSE12021, GSE55235, and GSE55457 were obtained from the GEO database, with GSE55457 being used as the validation set. After removing batch effects from the GSE12021 and GSE55235 datasets, the standardized combined dataset was obtained and used as the training dataset. Differentially expressed genes (DEGs) were identified from the training dataset. All nicotinamide metabolism-related genes (NMRGs) were obtained from the GeneCards and MSigDB databases. The intersection of DEGs and NMRGs was taken to obtain nicotinamide metabolism-related differentially expressed genes (NMRDEGs). Gene set enrichment analysis (GSEA) was performed on the training dataset, while gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) analysis were performed on NMRDEGs. Key genes were selected by using least absolute shrinkage and selection operator (LASSO) and support vector machine (SVM) analysis in NMRDEGs to build an osteoarthritis diagnosis model which was validated by using the GSE55457 dataset. Single sample gene set enrichment analysis (ssGSEA) was used to analyze the immune cell infiltration type. Interactions networks and drug molecule predictions were obtained for these key genes' mRNA with the DGIdb, ENCORI, and CHIPBase databases. siRNA was used to knock down the key genes in chondrocytes, and then real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of chondrogenesis-related genes. Results ·Seven NMRDEGs, including NAMPT, TIPARP, were discovered. GO and KEGG analysis enriched some signaling pathways, such as nuclear factor-κB signaling pathway and positive regulation of interleukin-1-mediated signaling pathway. GSEA enriched pathways such as Hif1 Tfpathway and syndecan 1 pathway. Key genes NPAS2, TIPARP, and NAMPT were identified through LASSO and SVM analysis, and used to construct an osteoarthritis diagnostic model. The validated results showed that the diagnostic model had high accuracy. Immune infiltration analysis results obtained by ssGSEA showed significant differences (all P<0.05) in 15 types of immune cells, including macrophages. Seven potential small molecules targeting key genes were identified, along with 19 miRNAs with the sum of upstream and downstream >10, 19 transcription factors with upstream and downstream >7, and 27 RNA binding proteins with clusterNum >19. The results of RT-qPCR showed that knocking down key genes reduced the expression of chondrogenesis-related genes. Conclusion ·Through bioinformatics analysis, key genes related to nicotinamide metabolism, NPAS2, TIPARP, and NAMPT, are discovered, and an osteoarthritis diagnostic model is constructed. Table and Figures | Reference | Related Articles | Metrics

Select

Establishment of a novel mice model of heart failure with preserved ejection fraction Xiao-nan CHEN, Jun-feng ZHANG, Chang-qian WANG, Hui-li ZHANG JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (5): 565-570.   DOI: 10.3969/j.issn.1674-8115.2021.05.002 Abstract （1625）   HTML （47）    PDF（pc） （2075KB）（1045）       Knowledge map    Save ·To establish a novel mice model of heart failure with preserved ejection fraction (HFpEF). ·Sixteen 8-week-old SPF grade male and female C57BL/6J mice each were randomly divided into control group or model group (n=8 per group). The model group was given high-fat diet containing 60% fat and drinking water containing 0.5 g/L Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME). The control group was given routine feed and drinking water. The ratio of peak early mitral velocity to peak late mitral velocity (E/A ratio) and the ratio of peak early mitral velocity to peak early diastolic mitral annular velocity (E/E' ratio) were detected by echocardiography every two weeks to evaluate left ventricular diastolic function. At the 16th week after modeling, the myocardial hypertrophy and fibrosis were examined by Masson staining and hematoxylin-eosin staining. The levels of serum triacylglycerol (TAG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-Ch) and low-density lipoprotein cholesterol (LDL-Ch) were detected by automatic biochemical analyzer. ·HFpEF appeared in the male mice at 8 weeks after high-fat diet and L-NAME administration, with a significant increase in E/A ratio and E/E′ ratio in comparison to the male control group (both P=0.000). There was no significant difference in the left ventricular ejection fraction (LVEF) between male model group and male control group. On the other hand, the female mice fed with high-fat diet and drinking water containing L-NAME also displayed obvious HFpEF after 8 weeks. E/A ratio and E/E' ratio in female model group were significantly higher than those in the female control group (P=0.000, P=0.001). There was no significant difference in LVEF between female model group and female control group. At the 16th week after modeling, both male and female mice still displayed the characteristics of HFpEF. Systolic blood pressure and diastolic blood pressure of male and female model group were significantly higher than those of respective control groups. Male or female mice with HFpEF showed obvious myocardial hypertrophy and fibrosis along with left ventricular remodeling. The serum levels of TAG, TC, HDL-Ch and LDL-Ch in the model groups were significantly higher than those in the respective control groups. ·High-fat feeding combined with L-NAME administration can induce HFpEF in both male and female mice. Table and Figures | Reference | Related Articles | Metrics

Select

Aptamer-drug conjugates (ApDCs): new trend for cancer precision therapy HAN Yongqi, HAN Da, XIA Qian, JI Dingkun, TAN Weihong Journal of Shanghai Jiao Tong University (Medical Science)    2022, 42 (9): 1176-1181.   DOI: 10.3969/j.issn.1674-8115.2022.09.003 Abstract （698）   HTML （211）    PDF（pc） （1279KB）（623）       Knowledge map    Save Cancer is a worldwide medical issue that seriously threatens human health. Precision molecular medicine provides a new strategy for cancer theranostics. As excellent targeting recognition molecules and drug delivery platforms, aptamers and aptamer drug-conjugates (ApDCs) have provided a series of useful molecular tools for cancer precision therapy. In this paper, the properties and the selection techniques of aptamers, the construction of ApDCs and their applications to clinical tumor-targeting therapy are reviewed. Additionally, the challenges and perspective of ApDCs in precision molecular medicine for cancers are presented. This review may provide new horizons for molecular-targeted anti-tumor drugs in the therapy of clinical malignant tumors. Reference | Related Articles | Metrics

Select

Interventions to enhance return-to-work among young and middle-aged cancer survivors: a systematic review ZHANG Yuanyuan, WU Anqi, WU Jie, ZHU Yaqi, LI Mengyao, YAN Dexiu, ZHANG Yaqing, HOU Lili Journal of Shanghai Jiao Tong University (Medical Science)    2023, 43 (3): 333-341.   DOI: 10.3969/j.issn.1674-8115.2023.03.009 Abstract （162）   HTML （14）    PDF（pc） （1743KB）（215）       Knowledge map    Save Objective ·To systematically evaluate the application of return-to-work intervention programs to young and middle-aged cancer survivors and its effectiveness in improving work-related outcomes in cancer survivors. Methods ·An initial literature search of eight electronic databases, including PubMed, Cochrane Library, Embase, CNKI and Wanfang was conducted with a time frame from inception to Aug 2nd, 2022 to collect randomized controlled trials (RCTs) and quasi-experimental studies of return-to-work interventions on work-related outcomes among cancer survivors. Two researchers independently conducted literature screening, data extraction, and methodological quality evaluation using the JBI (Joanna Briggs Institute) Methodology Quality Evaluation Tool. Results ·A total of 13 original studies were included, involving 11 return-to-work intervention programs, containing 2 045 cancer survivors. The results of the systematic evaluation showed that 10 of the intervention programs were multidisciplinary, with intervention modules on disease/mental health education, group discussions, physical rehabilitation, work capacity exercises, multidisciplinary team meetings and counselling. Among them, three interventions also included employers in the support program. The duration of the interventions ranged from 7 d to one year. Eight of the included interventions took return-to-work rates as a primary outcome, but only three reported that the difference was statistically significant, two of which were quasi-experimental studies without control group. Besides, no clear positive effects were found on work-related outcome such as length of return-to-work, change of work status, work ability, and work meaning. Conclusion ·The content, format, intensity and frequency of return-to-work intervention programs for cancer survivors vary widely, and the effects of interventions on work-related outcomes are still unclear. Researchers should further explore the mechanisms that influence cancer survivors′ return-to-work, and develop multidisciplinary intervention programs based on this to effectively help young and middle-aged cancer survivors return-to-work and society. In addition, due to the limitations of study quality and intervention program heterogeneity, more high-quality experimental studies are needed to further validate the above findings. Table and Figures | Reference | Related Articles | Metrics

Select

Effects of work stress, psychological resilience and perceived social support on compassion fatigue of nurses in assisted reproduction departments Yu-lian HU, Ya-qing ZHANG JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (12): 1565-1571.   DOI: 10.3969/j.issn.1674-8115.2021.12.004 Abstract （463）   HTML （21）    PDF（pc） （2407KB）（397）       Knowledge map    Save ·To understand the current status of work stress, psychological resilience, perceived social support, and compassion fatigue among assisted reproduction department nurses in China, and explore their quantitative relationship model on this basis. ·Using a convenience sampling method, 511 assisted reproduction department nurses from 32 tertiary hospitals in 17 provinces and cities in the eastern, central and western economic regions of China were surveyed from September to December 2020 with using a general information questionnaire, the Nurses' Work Stressor Scale, the Mental Toughness Scale, the Appreciative Social Support Scale and the Compassion Fatigue Scale. Through basic statistics and structural equation modeling, we constructed a quantitative relationship model among work stress, psychological resilience, perceived social support, and compassion fatigue, and analyzed the relationships among these variables and their effects on compassion fatigue among assisted reproduction department nurses in China. ·The mean item scores of the dimensions of compassion fatigue among nurses in our assisted reproduction departments were compassion satisfaction (3.68±0.63), job burnout (2.39±0.52), and secondary traumatic stress (2.46±0.56), all of which were at moderate levels; there was a correlation between work stress, psychological resilience, perceived social support, and compassion fatigue among nurses in assisted reproduction departments (all P=0.000).The results of structural equation modeling showed that job stress had a direct negative effect on compassion satisfaction (β=-0.34, P=0.000), a direct positive effect on compassion fatigue symptoms (β=0.25, P=0.000); psychological resilience had a direct positive effect on compassion satisfaction (β=0.53, P=0.000), and a direct negative effect on compassion fatigue symptoms (β=-0.29, P=0.000); psychological resilience mediated the effect between job stress and compassion fatigue symptoms and between job stress and compassion satisfaction, and appreciating the role of social support in compassion fatigue symptoms and compassion satisfaction was not significant. ·Compassion fatigue of nurses in our assisted reproduction departments is affected by a variety of factors, among which the role of psychological resilience is significant in improving compassion satisfaction. It is recommended to start from enhancing the psychological resilience of nurses, take effective measures to improve the psychological resilience of nurses, reduce the incidence of compassion fatigue of nurses, and thus improve the quality of care. Table and Figures | Reference | Related Articles | Metrics

Select

Application of Montreal Cognitive Assessment Scale to the elderly in Chinese community An-qi XIA, Jun LI, Ling YUE, Bo HONG, Feng YAN, Ning SU, Shi-fu XIAO, Yuan-yuan LIU, Tao WANG JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (12): 1662-1667.   DOI: 10.3969/j.issn.1674-8115.2021.12.017 Abstract （619）   HTML （18）    PDF（pc） （2168KB）（369）       Knowledge map    Save ·To update the cut-off value of the normal elderly (NE) and mild cognitive impairment (MCI) elderly in urban areas of China according to the Montreal Cognitive Assessment (MoCA) scores and analyze the sections of MoCA. ·A cross-sectional study was conducted to investigate the elderly over 60 years old in ten cities of China. Mini-Mental State Examination (MMSE) and MoCA (Beijing version) were used to assess cognitive function. Data was statistically analyzed by SPSS 19.0. ·There were 2 367 NE, 553 MCI patients, 1 319 males and 1 601 females, with an average age of (70.6±7.5) years and an average length of education of (8.7±5.2) years. There were significant difference in age and length of education between MCI and NE groups (t=12.3, P=0.000; t=-13.5, P=0.000). Female was more likely to have MCI (χ2＝13.5, P=0.000). By analyzing the score of MoCA of the NE, it was found that the MoCA score of males, high education level and low age group were higher. Rhinoceros and camel in naming, church and face in delayed memory, alternating connection test and pointer position in clock drawing were more difficult. The sections' scores of MoCA showed that the subjects performed better in the orientation and attention tests, while the scores of visuospatial functions, delayed recalling, sentence repetition and abstract ability were lower. The best cut-off value of MoCA was 20 (sensitivity = 63.7%, specificity = 75.7%). The area under the curve was 0.76. ·MoCA (Beijing version) has a good distinction between NE and MCI, and 20 can be used as a cut-off value in MCI subjects screening in urban areas of China. MoCA score is influenced by age, gender and education level. Based on difficulty analysis, some words that evaluate memory could be replaced (replacing “face” with “hand” and replacing “church” with “factory”). Table and Figures | Reference | Related Articles | Metrics

Select

Application progress of machine learning in the study of facial features of patients with depression Xin LI, Qing FAN JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2022, 42 (1): 124-129.   DOI: 10.3969/j.issn.1674-8115.2022.01.019 Abstract （783）   HTML （51）    PDF（pc） （832KB）（720）       Knowledge map    Save Major depressive disorder (MDD) is a mental illness that severely affects the quality of life, accompanied by changes in facial expressions and other behaviors. The current diagnosis for MDD mainly relies on self-reports and observations from doctors, which has subjective errors. There is a lack of objective and effective automated MDD detection methods. Facial expressions are important nonverbal behaviors, and the researchers have begun to use facial features to assist in identifying and diagnosing depression. As the core of artificial intelligence, machine learning has outstanding advantages in image feature extraction and classification. Taking IEEE Xplore database as the data source, this article sorts out the researches on the facial features of MDD patients based on machine learning from 2016 to 2021, and prospects the future research directions, to provide reference for clinical intelligent diagnosis and tracking of MDD in the future. Reference | Related Articles | Metrics

Select

Reliability and validity of the Chinese version of Perceived Stress Scale WANG Zhen, WANG Yuan, WU Zhi-guo, CHEN Dan-dan, CHEN Jue, XIAO Ze-ping    2015, 35 (10): 1448-.   DOI: 10.3969/j.issn.1674-8115.2015.10.004 Abstract （3154）      PDF（pc） （468KB）（2467）       Knowledge map    Save ObjectiveTo assess the reliability and validity of the Chinese version of Perceived Stress Scale (PSS-10).MethodsA total of 272 participants, including patients with depression and obsession and healthy volunteers, were selected and tested by the Chinese version of PSS-10, Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI). Thirty patients were randomly selected and retested by PSS-10 after 2 weeks.ResultsThe overall Cronbachs alpha of the Chinese version of PSS-10 was 0.91 and the test-retest reliability coefficient was 0.69 (P<0.05). The exploratory factor analysis (EFA) yielded two factors, i.e. the negative feelings (6 items) and positive feelings (4items). The confirmatory factor analysis (CFA) indicated that the fitting of the two factor model was perfect (χ2=44.52，P<0.107). The total score of PSS-10 significantly and positively correlated with scores of both BDI-II and BAI (P<0.01). The differences of scores of PSS-10 of three groups were significant (F=107.6，P<0.01). ConclusionThe reliability and validity of the Chinese version of PSS-10 are good and can be used as a self rating tool to assess the level of perceived stress. Related Articles | Metrics

Select

Fabrication of self-healing injectable hyaluronic acid hydrogel for promoting angiogenesis YANG Shu, CUI Wenguo, WEI Jie, CAI Zhengwei Journal of Shanghai Jiao Tong University (Medical Science)    2023, 43 (12): 1480-1492.   DOI: 10.3969/j.issn.1674-8115.2023.12.003 Abstract （108）   HTML （15）    PDF（pc） （7495KB）（136）       Knowledge map    Save Objective ·To construct a self-healing injectable hyaluronic acid (HA)-based hydrogel (HAPD-Cu) and investigate the effects of different copper ions on the properties of the hydrogel and its vasogenic efficacy to evaluate its feasibility for clinical wound healing. Methods ·Bisphosphonated hyaluronic acid (HAPD) was prepared via a blue-light mediated thiol-ene click reaction between thiolated hyaluronic acid (HASH) and acrylated bisphosphonate (Ac-PD) in the presence of photoinitiator 2959. Then, HAPD was further interacted with Cu2+ through metal coordination to prepare HAPD-Cu hydrogels with different Cu2+ concentrations, i.e. HAPD-Cu1, HAPD-Cu2, HAPD-Cu3 and HAPD-Cu4. The molecular structures of HASH, Ac-PD, HAPD and HAPD-Cu were verified with 1HNMR and FTIR. Microscopic morphology of HAPD-Cu was observed under SEM. The shear-thinning and self-healing properties of HAPD-Cu were verified by rheometer. The Cu2+ release from HAPD-Cu was determined with ICP. Live-dead staining and CCK-8 assay were applied to evaluate the biocompatibility of HAPD-Cu. The in vitro vasculogenic activity of HAPD-Cu was determined by a tubule-forming assay with human umbilical vein vascular endothelial cells and the in vivo vasculogenic activity of HAPD-Cu was assessed by CD31 tissue staining. A rat wound defect model was established in vitro to evaluate its actual repair effect. Results ·The preparation of the materials was demonstrated through chemical qualitative and quantitative analytical means. In vitro studies showed that all HAPD-Cu with a loose porous internal structure exhibited outstanding self-healing, injectability and degradability, with a one-week degradation cycle and abrupt release behavior, which can meet the needs of wound healing cycle. All HAPD-Cu showed good biocompatibility except HAPD-Cu4, due to its high Cu2+ concentrations. Moreover, its angiogenic effect in vitro or in vivo was enhanced with increasing Cu2+ concentrations within the permissible Cu2+ concentration range. In vitro wound model experiments also showed that the HAPD-Cu hydrogel significantly promoted wound healing compared with the control group. Conclusion ·HAPD-Cu hydrogel constructed via the metal coordination shows excellent shape plasticity, allowing the filling of defective sites in a minimally invasive form, and the release of Cu2+ greatly facilitates the establishment of early vascular networks, with giant potential for use in the repair of clinically irregular wounds. Table and Figures | Reference | Related Articles | Metrics

Select

Research progress of neuromodulation in the treatment of Parkinson 's disease HU Canfang, ZHONG Chuanyu, CAO Li Journal of Shanghai Jiao Tong University (Medical Science)    2024, 44 (2): 258-263.   DOI: 10.3969/j.issn.1674-8115.2024.02.012 Abstract （63）   HTML （23）    PDF（pc） （1216KB）（87）       Knowledge map    Save Parkinson's disease (PD) is a common degenerative neurological disorder, characterized by static tremor, bradykinesia, myotonia and postural abnormalities. Dopaminergic drugs are the main drugs in the treatment of PD, but long-term use will lead to drug efficacy loss, and even cause some adverse reactions such as dyskinesia and "on-off" phenomenon. Neuromodulation is a kind of biomedical engineering technology that can stimulate or inhibit the activity of brain neurons and regulate the changes of neuroplasticity by means of electric energy, magnetic field, ultrasound and other methods, so as to achieve treatment and improvement of diseases. In the non-drug treatment of PD, neuromodulation, as a new therapeutic means, has shown good efficacy, and has the advantages of small adverse reactions and easy tolerance. Based on this, this article reviews the research progress of several common neuromodulation in PD, including deep brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation and transcranial focused ultrasound. Reference | Related Articles | Metrics