上海交通大学学报（医学版）

上海交通大学学报（医学版）

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长链非编码RNAs及其调控血管新生的研究进展

刘 鹃1，汪 泱2，沈晓黎1，邓志锋1,3   

  1. 1.南昌大学第二附属医院神经外科， 南昌 330006； 2.上海交通大学附属第六人民医院四肢显微外科研究所， 上海 200233， 3.上海交通大学附属第六人民医院神经外科， 上海 200233
  • 出版日期:2013-09-28 发布日期:2013-09-29
  • 通讯作者: 邓志锋, 电子信箱: dengzf63@126.com。
  • 作者简介:刘 鹃（1987—）， 男， 硕士生; 电子信箱: pajingsen@126.com。
  • 基金资助:

    国家自然科学基金（81160154, 81272170）

Research progress of long non-coding RNAs and their role in regulation of angiogenesis

LIU Juan1, WANG Yang2, SHEN Xiao-li1, DENG Zhi-feng1,3   

  1. 1.Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; 2.Limbs Institute of Microsurgery, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200025, China; 3.Department of Neurosurgery, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2013-09-28 Published:2013-09-29
  • Supported by:

    National Natural Science Foundation of China, 81160154, 81272170

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摘要：

长链非编码RNAs（lncRNAs）是在基因组中普遍被转录的一类转录本长度超过200 nt的非编码蛋白RNA。近年来的研究表明，lncRNAs参与了X染色体沉默、基因组印记以及染色质修饰、转录激活、转录干扰和核内运输等多种重要的调控过程，这表明lncRNAs并不是基因组转录的“噪音”，而是以RNA的形式在多层面上（表观遗传调控、转录调控以及转录后调控等）调控基因的表达水平。该文总结lncRNAs的功能及其调控血管新生的最新研究进展。

关键词: 长链非编码RNAs, 血管新生, aHIF, MEG3, sONE, tie-1AS

Abstract:

Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcript RNAs with more than 200 nt in length, which are pervasively transcribed in the genome. Recent researches have demonstrated that lncRNAs affect many biological processes, including X-inactivation, genomic imprinting, chromatinmodifying, transcriptional activation, transcriptional interference and nuclear-cytoplasmic trafficking, which indicates lncRNAs are not transcriptional noise but functional as a regulater of the gene expression on the epigenetic, transcriptional and post-transcriptional levels. The research progress of lncRNAs functions and their role in the regulation of angiogenesis is reviewed in this paper.

Key words: long non-coding RNAs, angiogenesis, aHIF, MEG3, sONE, tie-1AS