上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（基础研究） • 上一篇    下一篇

抵抗素基因多态性与脑梗死的关系

顾琳,蔡高宇,陈淳,傅毅   

  1. 上海交通大学 医学院附属瑞金医院神经内科， 上海 200025
  • 出版日期:2016-02-28 发布日期:2016-03-29
  • 作者简介:顾琳（1981—）， 女， 主治医师， 硕士生; 电子信箱: gulin365@126.com。

Correlation between polymorphism of resistin gene and cerebral infraction

GU Lin, CAI Gao-yu, CHEN Chun, FU Yi   

  1. Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2016-02-28 Published:2016-03-29

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摘要：

目的 研究抵抗素基因-420C/G位点多态性与脑梗死之间是否存在相关性。方法 采用聚合酶链反应－高温连接酶检测反应技术，对426例脑梗死患者和305例健康对照者抵抗素基因-420C/G的多态性进行分析。结果 脑梗死组的总胆固醇（TC）与对照组比较，差异无统计学意义。脑梗死组的三酰甘油（TG）、低密度脂蛋白胆固醇(LDL-C)、血糖和血压高于对照组，而高密度脂蛋白胆固醇(HDL-C)则降低。脑梗死组患者的-420C/G基因型频率和等位基因频率与对照组比较，差异无统计学意义，两组样本都符合H-W检验。脑梗死危险因素的logistic回归分析显示，收缩压、空腹血糖、LDL-C和TG水平的差异是脑梗死的独立危险因素。结论 抵抗素基因-420C/G位点多态性与脑梗死无相关性。

关键词: 脑梗死, 抵抗素, 基因多态性

Abstract:

Objective To investigate the correlation between the polymorphism of locus -420C/G of the resistin gene and cerebral infraction. Methods The polymorphism of locus -420C/G of the resistin gene of 426 patients with cerebral infraction and 305 healthy controls was analyzed by PCR-LDR. Results The difference of TC between the cerebral infraction group and control group were not statistically significant. The TG, LDL-C, fasting blood glucose, and blood pressure of the cerebral infraction group were higher than those of the control group, while HDL-C was lower than that of the control group. The differences of genotype frequency and allele frequency of -420C/G gene between the cerebral infraction group and control group were not statistically significant. Samples of both groups accorded with the H-W test. The logistic regression analysis showed that sytolic pressure, fasting blood glucose, LDL-C, and TG were independent risk factors of cerebral infraction. Conclusion The polymorphism of locus -420 C/G of the resistin gene does not correlate to cerebral infraction.

Key words: cerebral infraction, resistin, gene polymorphism