上海交通大学学报（医学版）

上海交通大学学报（医学版）

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细胞分裂周期蛋白42在肿瘤发生发展和治疗中作用的最新进展

张宇，杨德君，颜荣林   

  1. 第二军医大学附属长征医院胃肠外科， 上海 200003
  • 出版日期:2016-05-28 发布日期:2016-05-26
  • 通讯作者: 颜荣林, 电子信箱: yanronglin12@sina.com。
  • 作者简介:张宇（1990—）， 男， 硕士生; 电子信箱: zhang-yu10086@163.com。
  • 基金资助:

    国家自然科学基金（30972953）

Latest advances in the role of cell division cycle 42 in tumor occurrence, development, and treatment

ZHANG Yu, YANG De-jun, YAN Rong-lin   

  1. Department of Gastrointestinal Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Online:2016-05-28 Published:2016-05-26
  • Supported by:

    National Natural Science Foundation of China, 30972953

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摘要：

细胞分裂周期蛋白42（Cdc42）是一类广泛表达的小三磷酸鸟苷（GTP）酶，因其具有GTP酶活性，因而又被称为Rho GTP酶。Cdc42可以调节细胞骨架的形态学改变，并调节诸如细胞生长和增殖、细胞活力、细胞极性等生理过程中涉及的膜运输功能。Cdc42在多种恶性肿瘤中呈现高表达，并和肿瘤的发生、侵袭和转移密切相关，提示Cdc42可能为肿瘤治疗的潜在靶点。该文拟从Cdc42的形态结构、功能、信号通路上下游效应分子以及在人类肿瘤侵袭和转移中的作用等方面进行综述。

关键词: Rho GTP酶, 细胞分裂周期蛋白42, 信号通路, 微小RNA, 肿瘤

Abstract:

Cell division cycle 42 (Cdc42) is one of ubiquitously expressed guanosine triphosphate enzymes (GTPases), which are also known as Rho GTPases due to their GTPase activity. Cdc42 can regulate morphologic changes of the cytoskeleton and membrane transport function involving in physiological processes such as growth, proliferation, motility, and polarity of cells. Cdc42 is highly expressed in a variety of malignancies and is closely associated with tumor progression, invasion, and metastasis, which suggest Cdc42 may be a potential target for the treatment of tumors. This paper reviews Cdc42 with respect to its structure, functions, up-stream and down-stream effectors, as well as its role in tumor invasion and metastasis.

Key words: Rho GTPases, cell division cycle 42, signal pathway；microRNAs, cancerRho