上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (5): 510-.doi: 10.3969/j.issn.1674-8115.2019.05.012

• 论著·临床研究 • 上一篇    下一篇

博来霉素预防翼状胬肉术后复发的临床观察

陈俊曌，赵展琳，姚钦科，邵春益，傅瑶   

  1. 上海交通大学医学院附属第九人民医院眼科 ,上海市眼眶病眼肿瘤重点实验室，上海 200011
  • 出版日期:2019-05-28 发布日期:2019-07-26
  • 通讯作者: 傅瑶，电子信箱：fuyaofy@sina.com。
  • 作者简介:陈俊曌（1986—），男，住院医师，博士生；电子信箱： lydie_007@126.com。
  • 基金资助:
    国家自然科学基金（ 81600774，81770888）；上海市眼眶病眼肿瘤重点实验室资助项目（ 17DZ2260100）；上海市教育委员会高峰高原计划学科建设计划（ 20161421）；上海市科学技术委员会科技成果转化和产业化项目（ 17411963800）；上海交通大学医学院附属第九人民医院临床研究助推计划（ JYLJ014）

Clinical observation on prevention of pterygium recurrence with bleomycin in pterygium surgery

CHEN Jun-zhao, ZHAO Zhan-lin, YAO Qin-ke, SHAO Chun-yi, FU Yao   

  1. Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China
  • Online:2019-05-28 Published:2019-07-26
  • Supported by:
    National Natural Science Foundation of China, 81600774，81770888; Foundation of Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 17DZ2260100; Shanghai Municipal Education Commission— GaoFeng Clinical Medicine Support, 20161421; Founda

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摘要： 目的 ·评价翼状胬肉术中应用博来霉素预防术后复发的临床疗效。方法 ·回顾性研究 59例（82眼）翼状胬肉患者资料，在胬肉切除联合自体结膜瓣移植手术中局部使用博来霉素（ 3 mg/mL），观察术后角膜、结膜愈合情况，评价术后复发率和并发症。结果 ·所有患者术后观察随访 6个月及以上，平均（ 18.5±9.7）个月，术眼角膜透明，结膜瓣愈合良好，与周围组织融合，无明显瘢痕增生，随访期间胬肉无复发；所有患者均未发生持续性角膜上皮缺损、巩膜缺血溶解、睑球粘连、继发性青光眼和白内障等并发症。结论 ·抗代谢药博来霉素的局部应用可能可以降低翼状胬肉的术后复发率，且不引起严重的并发症。

关键词: 翼状胬肉, 博来霉素, 复发

Abstract:

Objective · To observe the clinical effect of bleomycin for prevention of recurrence after pterygium treatment. Methods · Pterygium excision surgery combined with conjunctival autograft transplantation method on 59 patients (82 eyes) was performed, bleomycin (3 mg/mL) was used to prevent recurrence during the surgery. Corneal and conjunctival wound healing, recurrence rate and complications were observed in all the patients after surgery. Results · All the patients were followed-up for 6 months or more [(18.5±9.7) months]. After surgery, the corneas were transparent; the conjunctival flaps healed well and fused with surrounding tissues; no obvious scar hyperplasia and no recurrence of pterygium occured during the follow-up. None of the patients had sustained corneal epithelial defect, scleral ischemia, symblepharon, secondary glaucoma or cataract. Conclusion · The application of bleomycin may reduce the recurrence rate of pterygium effectively without serious complications.

Key words: pterygium, bleomycin, recurrence

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