上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (6): 593-.doi: 10.3969/j.issn.1674-8115.2019.06.006

• 论著·临床研究 • 上一篇    下一篇

精神病临床高危人群及首发精神分裂症患者听觉事件相关电位P300的 θ频谱改变

郭茜 1*，王俊杰 2*，刘旭 3，郑丽娜 4，李冠军 1，李金 2，王继军 5   

  1. 1. 上海交通大学医学院附属精神卫生中心早期精神病性障碍科，上海 200030；2.江苏省苏州市广济医院，苏州大学附属广济医院，苏州 215137；3. 中国科学院神经科学研究所，上海 200031；4.山东省聊城市人民医院精神心理科，聊城 252000；5. 上海交通大学医学院附属精神卫生中心脑电影像眼动研究室，上海 200030
  • 出版日期:2019-06-28 发布日期:2019-07-26
  • 通讯作者: 王继军，电子信箱：jijunwang27@163.com。
  • 作者简介:郭茜（1984—），女，主治医师，博士生；电子信箱： guoqian1205@vip.163.com。王俊杰（1978—），住院医师，博士；电子信箱： wangjunjie6723@163. com。*为共同第一作者。
  • 基金资助:
    国家自然科学基金（81501152）；国家科技部“十三五重大慢性非传染性疾病防控研究”重点专项（2016YFC1306800）；上海市精神卫生中心“飞翔计划”人才项目 (2018-FX-04)；上海交通大学医学院“博士创新基金”项目（BXJ201743）；上海市卫生和计划生育委员会科研课题计划（201540314）

Abnormality of θ oscillation in auditory event-related potential P300 in patients with clinical high risk of psychosis or first-episode schizophrenia

GUO Qian1*, WANG Jun-jie2*, LIU Xu3, ZHENG Li-na4, LI Guan-jun1, LI Jin2, WANG Ji-jun5   

  1. 1. Department of Early Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Suzhou Guangji Hospital, Jiangsu Province; Affiliated Guangji Hospital of Soochow University, Suzhou 215137, China; 3. Institute of Neuroscience, Shanghai Institute for Biological Science, Chinese Academy of Science, Shanghai 200031, China; 4. Department of Psychiatry and Psychology, Liaocheng People’s Hospital, Liaocheng 252000, China; 5. Department of Electroencephalography and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-06-28 Published:2019-07-26
  • Supported by:
    National Natural Science Foundation of China, 81501152; Key Special Project of “Major Chronic Non-communicable Diseases Prevention and Control Research in the 13th Five-year Plan” of Ministry of Science and Technology, China, 2016YFC1306800; Talents Project of “Flying Plan” of Shanghai Mental Health Center, 2018-FX-04; “Innovation Foundation for Postgraduate”Project of Shanghai Jiao Tong University School of Medicine, BXJ201743; Scientific Research Project of Shanghai Municipal Commission of Health and Family Planning, 201540314）。

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摘要： 目的 ·探索精神病临床高危（clinical high risk，CHR）人群和首发精神分裂症（first episode schizophrenia，FES）患者听觉事件相关电位 P300的 θ振荡改变，以及与临床症状之间的关系。方法 ·招募 18名精神病 CHR患者（CHR组）、 18名 FES患者（FES组）以及 19名健康对照（健康对照组），完成标准听觉 Oddball实验范式，并用 64导联脑电帽记录脑电活动。选择 Fz、Cz、Pz电极进行 P300波幅、峰潜伏期以及 P300的 θ振荡时－频分析。结果 · 3组被试的 P300波幅间差异有统计学意义（P0.004），其中 FES组（P0.001）及 CHR组（P0.026）的波幅均显著小于健康对照组， CHR组和 FES组间差异无统计学意义（P>0.05）。θ引发能量值在 3组间有显著差异（P0.022），其中 FES组显著低于健康对照组（P0.008），CHR组边缘性低于健康对照组（P0.054），CHR组与 FES组间差异无统计学意义（P>0.05）。θ诱发能量值在 3组间仅有边缘性差异（P0.054）。相关性分析发现， FES组的阳性与阴性症状量表总分及部分分量表评分与 Cz电极、 Pz电极的 P300波幅具有显著相关性（均 P<0.05）。结论 · CHR与 FES患者的听觉 P300波幅以及 P300的 θ振荡均存在异常，但 CHR患者的改变较 FES患者轻微，且其 P300的 θ振荡仅局限于引发能量受损，而诱发能量并未受损。

关键词: 精神病临床高危人群, 首发精神分裂症, &, theta, 振荡, 诱发能量, 引发能量

Abstract:

Objective · To explore the relationship between θ oscillation of auditory event-related potential P300 and clinical symptoms in the patients with clinical high risk (CHR) of psychosis or first episode schizophrenia (FES). Methods · A total of 18 patients with CHR of psychosis (CHR group), 18 patients with FES (FES group) and 19 healthy controls (control group) were recruited to complete the standard auditory Oddball paradigm as well as electroencephalogram (EEG) recording with 64-channel EEG cap. Fz, Cz and Pz electrodes were selected to compare the amplitudes and peak latent periods among the three groups, and time-frequency analysis of the θ oscillation in P300 was performed. Results · There was significant difference in the amplitudes of P300 among the three groups (P0.004). The amplitudes of P300 in FES group (P0.001) and CHR group (P0.026) were both significantly lower than that of control group. There was no difference between CHR group and FES group in P300 amplitude (P>0.05). θ Oscillation induced power was significantly different among the three groups (P0.022). The induced power value of FES group was significantly lower than that of control group (P0.008); and it was marginally lower in CHR group as compared to that of control group (P0.054). There was no difference between CHR group and FES group (P>0.05). There was trending difference in θ oscillation evoked power among the three groups (P0.054). The correlation analysis showed that the total and subscale scores of Positive and Negative Syndrome Scale in FES group were significantly correlated with the amplitudes of P300 at Cz and Pz electrodes (P<0.05). Conclusion · There are significant abnormalities in the amplitude of auditory P300 and θ oscillation of P300 in both CHR and FES patients; however, the change in CHR patients is less severe than that of FES patients. The impaired θ oscillation of P300 in CHR patients is limited to induced power, but evoked power is not impaired.

Key words: clinical high risk population of psychosis, first episode schizophrenia (FES), &, theta, oscillation, evoked power, induced power

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