上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (07): 943-949.doi: 10.3969/j.issn.1674-8115.2020.07.013

• 论著·临床研究 • 上一篇    下一篇

慢性牙周炎在腹膜透析患者中的发病状况及其与患者透析充分性的相关性研究

邓 海1，佟 琰1，Kristine SUN2，夏欣怡2，李 璞1，张春丽1，胡 春1，宋忠臣2，刘英莉1   

  1. 1. 上海交通大学医学院附属第九人民医院肾脏内科，上海 200011；2.上海交通大学医学院附属第九人民医院?口腔医学院牙周病科，国家口腔疾病临床医学研究中心，上海市口腔医学重点实验室，上海市口腔医学研究所，上海 200011
  • 出版日期:2020-07-28 发布日期:2020-09-23
  • 通讯作者: 刘英莉，电子信箱：18616375719@163.com。
  • 作者简介:邓 海（1995—），男，苗族，硕士生；电子信箱：tan.guang@tom.com。
  • 基金资助:
    上海交通大学医学院附属第九人民医院临床研究助推计划(jylj2018011)。

Prevalence of chronic periodontitis in peritoneal dialysis patients and its correlation with dialysis adequacy

DENG Hai1, TONG Yan1, Kristine SUN2, XIA Xin-yi2, LI Pu1, ZHANG Chun-li1, HU Chun1, SONG Zhong-chen2, LIU Ying-li1   

  1. 1. Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; 2. Department of Periodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China
  • Online:2020-07-28 Published:2020-09-23
  • Supported by:
    Clinical Research Program of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (jylj2018011).

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摘要： 目的·基于单中心人群分析腹膜透析患者慢性牙周炎（chronic periodontitis，CP）的发病状况，探讨CP严重程度与腹膜透析充分性指标的相关性。方法·选取2018年12月—2019年12月于上海交通大学医学院附属第九人民医院肾脏内科腹膜透析患者，符合入选标准者共57例。收集患者基线资料，透析充分性评价指标，包括尿素清除指数、肌酐清除率等，及其他相关生化指标，同时收集CP相关指标，包括临床附着丧失、牙龈指数、探诊深度。比较患者不同严重程度CP的腹膜透析患者透析充分性相关指标及指标达标率的差异，采用Pearson相关性分析、线性回归分析探讨CP相关指标与腹膜透析充分性指标之间相关性。结果·入选的所有腹膜透析患者均患有中度或重度的CP，中度CP患病率为24.6%，重度CP患病率为75.4%。重度CP组中、重度贫血的比例高于中度CP组（28.0% vs 14.3%），但差异无统计学意义（P>0.05）；2组的透析充分性评价指标及指标达标率之间差异也均无统计学意义（均P>0.05）。CP相关指标与透析充分性相关指标间无明显相关性（均P>0.05）。结论·腹膜透析患者中、重度CP患病率较高，同时患有重度CP的腹膜透析患者可能有发生中、重度贫血倾向；CP的严重程度与腹膜透析患者透析充分性之间未发现明显相关性。

关键词: 腹膜透析, 慢性牙周炎, 透析充分性, 贫血

Abstract:

Objective · To analyze the prevalence of chronic periodontitis (CP) in the peritoneal dialysis patients based on a single-center population, and explore the correlation between the severity of CP and the adequacy of peritoneal dialysis. Methods · A total of 57 patients undergoing peritoneal dialysis in the Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from December 2018 to December 2019 were included in the study. Baseline data, indicators of dialysis adequacy, including Kt/V, creatinine clearance rate, etc., and other related biochemical indicators were collected, and at the same time the CP-related indicators including clinical attachment loss, gingival index and probing depth were collected. The indicators of dialysis adequacy or their control rates of the patients with different severity of CP were compared. Pearson correlation analysis and linear regression analysis were used to explore the correlation between CP-related indexes and the indicators of dialysis adequacy. Results · All the patients undergoing peritoneal dialysis included in this study have moderate to severe CP. The prevalence of moderate CP was 24.6%, and the prevalence of severe CP was 75.4%. The proportion of moderate to severe anemia in the severe CP group was higher than that in the moderate CP group (28.0% vs 14.3%), but the difference was not statistically significant (P>0.05). Between the moderate and severe CP group, there was no statistical difference in the indicators of dialysis adequacy and their control rates (P>0.05). And there was no correlation between CP-related indexes and the indicators of dialysis adequacy as well (P>0.05). Conclusion · The prevalence of moderate to severe CP is very high in the peritoneal dialysis patients, in whom those with severe CP may have a tendency to develop moderate to severe anemia. There is no correlation between the severity of CP and dialysis adequacy.

Key words: peritoneal dialysis, chronic periodontitis (CP), dialysis adequacy, anemia

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