SUMO化修饰在精子发生过程中的作用

doi:10.3969/j.issn.1674-8115.2022.07.012

上海交通大学学报（医学版） ›› 2022, Vol. 42 ›› Issue (7): 925-930.doi: 10.3969/j.issn.1674-8115.2022.07.012

• 综述 • 上一篇

SUMO化修饰在精子发生过程中的作用

栾家妍(), 李朋, 韩邦旻()

上海交通大学医学院附属第一人民医院泌尿外科临床医学中心，上海 200080

收稿日期:2022-02-11 接受日期:2022-07-01 出版日期:2022-07-28 发布日期:2022-09-04
通讯作者: 韩邦旻 E-mail:suerljy@163.com;hanbm@163.com
作者简介:栾家妍（1997—），女，博士生；电子信箱：suerljy@163.com。
基金资助:
上海市“科技创新行动计划”医学创新研究专项项目(20Y11907600);国家自然科学基金(82171586)

Role of SUMOylation in spermatogenesis

LUAN Jiayan(), LI Peng, HAN Bangmin()

Urology Clinical Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China

Received:2022-02-11 Accepted:2022-07-01 Online:2022-07-28 Published:2022-09-04
Contact: HAN Bangmin E-mail:suerljy@163.com;hanbm@163.com
Supported by:
Medical Innovation Research Project of Shanghai Scientific and Technological Project(20Y11907600);National Natural Science Foundation of China(82171586)

摘要/Abstract

摘要：

SUMO化修饰（SUMOylation）是一种可逆的蛋白质翻译后修饰方式，参与转录调节、信号转导及DNA损伤修复等多个重要的生物学过程。研究发现，SUMO化修饰的整体表达和定位在精子的发生过程中呈动态变化，推测其可能参与了精子发生中的关键事件。精子发生是由复杂网络调控的一系列过程，即在生精小管中生精细胞经精原干细胞的增殖和分化、精母细胞的减数分裂以及精子变形3个阶段，最终形成高度特化的成熟精子。而在这一过程中，SUMO化修饰的作用及其具体机制尚未被明确。因此，该文就SUMO化修饰酶系、SUMO家族以及SUMO特异性蛋白酶家族在精子发生过程中的作用进行综述。

关键词: 精子发生, SUMO化修饰, 翻译后修饰

Abstract:

SUMOylation is a reversible post-translational modification of proteins, which is involved in many important biological processes, such as transcriptional regulation, signal transduction, and DNA damage repair. It is found that the overall expressions and localizations of SUMOylation change dynamically in spermatogenesis, suggesting that it may be involved in key events in the process. Spermatogenesis is a series of processes regulated by complex biological crosstalk. In the seminiferous tubules, spermatogenic cells undergo three stages, that is, the proliferation and differentiation of spermatogonial stem cells, the meiosis of spermatocytes and spermiogenesis, and eventually form highly specialized spermatozoa. In this process, the effects and mechanisms of SUMOylation in spermatogenesis have not been clear. Therefore, this review summarizes the effect of the SUMOylation enzyme system, SUMO family and SUMO-specific proteases family in spermatogenesis.

Key words: spermatogenesis, SUMOylation, post-translational modification

中图分类号:

R339.2⁺1

栾家妍, 李朋, 韩邦旻. SUMO化修饰在精子发生过程中的作用[J]. 上海交通大学学报（医学版）, 2022, 42(7): 925-930.

LUAN Jiayan, LI Peng, HAN Bangmin. Role of SUMOylation in spermatogenesis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(7): 925-930.

图/表 1

参考文献 47

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SUMO化修饰在精子发生过程中的作用

Role of SUMOylation in spermatogenesis

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