妊娠期糖尿病女性肠道菌群的变化特征及其与血糖、血脂和膳食的相关性

doi:10.3969/j.issn.1674-8115.2022.09.022

上海交通大学学报（医学版） ›› 2022, Vol. 42 ›› Issue (9): 1336-1346.doi: 10.3969/j.issn.1674-8115.2022.09.022

妊娠期糖尿病女性肠道菌群的变化特征及其与血糖、血脂和膳食的相关性

王婕¹^,²(), 吴慧³(), 卢凌鹏⁴, 杨科峰¹^,²^,⁵, 祝捷⁶, 周恒益¹^,², 姚蝶¹^,², 高雅¹^,², 冯宇婷¹^,², 刘玉红⁷(), 贾洁¹^,²^,⁵()

^1.上海交通大学医学院附属新华医院临床营养科，上海 200092
^2.上海交通大学医学院医学技术学院临床营养系，上海 200025
^3.上海中医药大学附属第七人民医院营养科，上海 200137
^4.上海中医药大学附属第七人民医院医学检验科，上海 200137
^5.上海交通大学医学院附属新华医院上海市小儿消化与营养重点实验室，上海 200092
^6.School of Family and Consumer Sciences，Texas State University，San Marcos 78666
^7.上海中医药大学附属第七人民医院妇产科，上海 200137

收稿日期:2022-05-18 接受日期:2022-08-19 出版日期:2022-09-28 发布日期:2022-09-28
通讯作者: 刘玉红,贾洁 E-mail:wangjie_1111@alumni.sjtu.edu.cn;liuyuhong0121@126.com;jie.jia@shsmu.edu.cn
作者简介:王　婕（1999—），女，本科生；电子信箱：wangjie_1111@alumni.sjtu.edu.cn
吴　慧（1984—），女，主治医师，硕士；电子信箱：whky22@qq.com第一联系人：（王婕和吴慧为本文共同第一作者）
基金资助:
国家自然科学基金(81501338);上海交通大学医学院大学生创新训练计划(S202010248405);上海中医药大学校级课题(2019LK042)

Dynamic changes in gut microbiota of women with gestational diabetes mellitus and the correlation with blood glucose, blood lipid and diet

WANG Jie¹^,²(), WU Hui³(), LU Lingpeng⁴, YANG Kefeng¹^,²^,⁵, ZHU Jie⁶, ZHOU Hengyi¹^,², YAO Die¹^,², GAO Ya¹^,², FENG Yuting¹^,², LIU Yuhong⁷(), JIA Jie¹^,²^,⁵()

^1.Department of Clinical Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
^2.Department of Clinical Nutrition, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
^3.Department of Nutrition, Shanghai Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
^4.Department of Medical Laboratory, Shanghai Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
^5.Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
^6.School of Family and Consumer Sciences, Texas State University, San Marcos 78666, America
^7.Department of Obstetrics and Gynecology, Shanghai Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China

Received:2022-05-18 Accepted:2022-08-19 Online:2022-09-28 Published:2022-09-28
Contact: LIU Yuhong,JIA Jie E-mail:wangjie_1111@alumni.sjtu.edu.cn;liuyuhong0121@126.com;jie.jia@shsmu.edu.cn
Supported by:
National Natural Science Foundation of China(81501338);Undergraduate Innovation Program of Shanghai Jiao Tong University School of Medicine(S202010248405);Funding of Shanghai University of Traditional Chinese Medicine(2019LK042)

摘要/Abstract

摘要：

目的·探索妊娠期糖尿病（gestational diabetes mellitus，GDM）女性在孕中期至孕晚期的肠道菌群变化特征，及其与膳食摄入、血糖及血脂水平的相关性。方法·2019年6月—2021年1月于上海中医药大学附属第七人民医院妇产科门诊招募定期产检的孕中期女性78人，其中GDM女性30人（GDM组）、健康妊娠女性48人（对照组）。收集并分析2组孕妇的人口学信息及血生化指标。采用半定量食物频率问卷对2组孕妇的膳食摄入情况进行比较。分别于孕中期、孕晚期收集2组孕妇的粪便样本，通过16S rRNA 高通量测序比较孕中期、孕晚期的GDM组和对照组孕妇的肠道菌群特征和其相似性。通过Spearman相关性热图分析孕中期孕妇的肠道菌群丰度与环境因子（血生化指标、膳食摄入成分）的关联。结果·与对照组相比，GDM组孕妇的孕期增重较多（P=0.012）。在孕中期，GDM组孕妇的空腹血糖水平、口服葡萄糖耐量试验（oral glucose tolerance test，OGTT） 1 h和OGTT 2 h血糖水平、三酰甘油水平高于对照组，高密度脂蛋白和低密度脂蛋白水平低于对照组（均P<0.05）。孕期膳食摄入的结果显示，GDM组孕妇的脂肪摄入水平高于对照组（P=0.046）。从孕中期至孕晚期，GDM组和对照组孕妇的肠道菌群α-多样性、β-多样性间差异均无统计学意义。孕中期GDM组与孕晚期GDM组、孕中期对照组、孕晚期对照组的属水平菌群结构相似性最小，而孕晚期GDM组与对照组的菌属构成相似性最高。Spearman相关性热图的结果显示，丁酸球菌科（Butyricicoccaceae）的丰度与膳食纤维和蔬菜摄入水平呈正相关（r=0.365，P=0.024；r=0.469，P=0.003），克雷伯菌（Klebsiella）的丰度与三酰甘油水平呈正相关（r=0.329，P=0.044），双歧杆菌（Bifidobacterium）的丰度与OGTT 2 h血糖水平呈负相关（r=-0.364，P=0.025）。结论·孕中期GDM组和对照组孕妇的肠道菌群组成较孕晚期存在较多显著差异物种，孕中期GDM相关的肠道菌群失调可能与糖脂代谢，膳食脂肪和蔬菜摄入水平存在关联。

关键词: 妊娠期糖尿病, 肠道菌群, 膳食, 糖脂代谢

Abstract:

Objective ·To explore the changes of gut microbiota in the women with gestational diabetes mellitus (GDM) during the second to the third trimesters of pregnancy, and the correlation with dietary intake and glucose-lipid metabolism. Methods ·From June 2019 to January 2021, 78 pregnant women (30 GDM women in the GDM group and 48 healthy women in the control group) in the second trimester of pregnancy were recruited from the Department of Obstetrics and Gynecology of Shanghai Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine. Demographic information and blood biochemical indicators of the two groups were collected and analyzed. A semi-quantified Food-Frequency Questionnaire (FFQ) was used to compare the dietary intake of the two groups of pregnant women. Fecal samples were collected in both groups at the second and the third trimesters of pregnancy, respectively. The characteristics and similarities of gut microbiota in both groups at the second and the third trimesters were compared by 16S rRNA high-throughput sequencing. Spearman correlation heatmap was used to analyze the relation between the abundance of gut microbiota and environmental factors (blood biochemical indicators and dietary intake components) in the pregnant women at the second trimester. Results ·Compared with the control group, the women in the GDM group gained more weight during pregnancy (P=0.012). In the second trimester, compared with the control group, the fast blood glucose level, the blood glucose level at oral glucose tolerance test (OGTT) 1 h and 2 h, and the triacylglycerol level of the pregnant women in the GDM group were higher, and the high-density lipoprotein and the low-density lipoprotein levels were lower (all P<0.05). The results of dietary intake during pregnancy showed that the fat intake level of the pregnant women in the GDM group was higher than that in the control group (P=0.046). From the second to the third trimester of pregnancy, there was no significant difference in the α-diversity and β-diversity of gut microbiota between the GDM group and the control group. The gut bacterial composition at genus level of the GDM group at the second trimester had the least similarity with that of the other three groups (GDM group at the third trimester, control group at the second trimester and the third trimester), while the GDM group and control group had the most similar gut bacterial composition at genus level in the third trimester. Spearman correlation heatmap analysis showed that the abundance of Butyricicoccaceae was positively correlated with dietary fiber and vegetable intake level (r=0.365, P=0.024; r=0.469, P=0.003), the abundance of Klebsiella was positively correlated with triacylglycerol level (r=0.329, P=0.044), and the abundance of Bifidobacterium was negatively correlated with blood glucose level at OGTT 2 h (r=-0.364, P=0.025). Conclusion ·The composition of gut microbiota of pregnant women in the GDM group and control group in the second trimester of pregnancy is significantly different from that in the third trimester of pregnancy. The disorder of gut microbiota related to GDM in the second trimester of pregnancy may be related to glucose-lipid metabolism, dietary fat and vegetable intake level.

Key words: gestational diabetes mellitus (GDM), gut microbiota, diet, glucose-lipid metabolism

中图分类号:

R459.3

王婕, 吴慧, 卢凌鹏, 杨科峰, 祝捷, 周恒益, 姚蝶, 高雅, 冯宇婷, 刘玉红, 贾洁. 妊娠期糖尿病女性肠道菌群的变化特征及其与血糖、血脂和膳食的相关性[J]. 上海交通大学学报（医学版）, 2022, 42(9): 1336-1346.

WANG Jie, WU Hui, LU Lingpeng, YANG Kefeng, ZHU Jie, ZHOU Hengyi, YAO Die, GAO Ya, FENG Yuting, LIU Yuhong, JIA Jie. Dynamic changes in gut microbiota of women with gestational diabetes mellitus and the correlation with blood glucose, blood lipid and diet[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(9): 1336-1346.

图/表 8

表1 GDM组与对照组孕妇的人口学信息和血生化指标比较

Tab 1 Comparison of demographic information and blood biochemical indicators between the GDM group and control group

Item	GDM group （n=30）	Control group （n=48）	P value
Age/year	29.90±4.21	28.90±4.15	0.304
Pre-pregnancy BMI/（kg·m^-2）	23.01 （20.36， 24.92）	21.20 （19.31， 23，73）	0.216
Weight gain/kg	15.74±4.80	12.63±5.77	0.012
Gravidity/n （%）			0.777
1	14 （46.67）	24 （50.00）
2	7 （23.33）	13 （27.08）
≥3	9 （30.00）	11 （22.92）
Parity/n （%）			0.277
Nulliparous	15 （50.00）	30 （62.50）
Multiparous	15 （50.00）	18 （37.50）
Educational background/n （%）			0.901
Middle school or below	5 （16.67）	7 （14.58）
High school	6 （20.00）	8 （16.67）
College	17 （56.67）	31 （64.58）
Graduate or above	2 （6.67）	2 （4.17）
FBG/（mmol·L^-1）	5.00±0.57	4.35±0.22	0.000
Blood glucose level at OGTT/（mmol·L^-1）
1 h	10.01±1.62	7.29±1.41	0.000
2 h	7.75±1.80	6.07±0.90	0.000
TC/（mmol·L^-1）	5.27±0.85	5.54±1.03	0.239
TAG/（mmol·L^-1）	3.00±1.32	2.12±0.67	0.003
HDL/（mmol·L^-1）	1.83±0.28	2.00±0.28	0.014
LDL/（mmol·L^-1）	2.67±0.65	3.07±0.90	0.040

表2 GDM组与对照组孕妇的膳食摄入比较

Tab 2 Comparison of dietary intake between the GDM group and control group

Item	GDM group （n=30）	Control group （n=48）	P value
Nutrient intake
Energy/（J·d^-1）	6 425 408.09 （5 415 822.49， 8 290 414.36）	6 510 632.03 （5 251 444.09， 7 870 154.84）	0.475
Protein/（g·d^-1）	59.20 （51.30， 77.50）	59.70 （47.15， 71.60）	0.853
Fat/（g·d^-1）	49.40 （34.50， 55.10）	34.90 （26.10， 47.10）	0.046
Carbohydrate/（g·d^-1）	197.40 （178.10， 268.00）	211.80 （184.20， 249.20）	0.951
Fiber/（g·d^-1）	16.60 （14.40， 21.70）	17.00 （13.20， 21.80）	0.622
BCAA/（mg·d^-1）	6 340.50 （5 417.60， 7 442.50）	5 952.00 （4 212.35， 7 364.00）	0.983
PUFA/（g·d^-1）	6.90 （2.50， 8.90）	4.30 （2.70， 6.80）	0.363
MUFA/（g·d^-1）	5.70 （4.30， 7.90）	4.90 （3.10， 7.30）	0.317
SFA/（g·d^-1）	7.60 （5.50， 8.60）	7.20 （5.65， 8.70）	0.914
Food intake/（g·d^-1）
Staple	165.40 （140.70， 196.20）	179.00 （128.60， 251.25）	0.593
Vegetable	437.60 （335.90， 779.00）	639.30 （445.80， 819.10）	0.072
Fruit	506.70 （394.80， 628.60）	437.10 （294.30， 646.40）	0.319
Egg	60.00 （30.00， 64.00）	60.00 （38.60， 90.00）	0.374
Meat	50.10 （34.30， 67.10）	35.70 （21.50， 56.00）	0.111
Fish	41.40 （13.00， 78.60）	42.90 （28.25， 78.60）	0.583
Bean	77.70 （21.40， 131.40）	50.00 （22.60， 97.60）	0.655
Dairy	271.40 （200.00， 320.00）	250.00 （188.00， 305.95）	0.701
Dried fruit	16.00 （6.40， 30.00）	14.30 （3.80， 20.00）	0.318

图1 孕中期（T2）至孕晚期（T3）GDM组和对照组孕妇肠道菌群的α-多样性比较Note： A. Sob index. B. Shannon index. C. Simpson index. D. Chao1 index. GDM—GDM group; CON—Control group; T2—2nd trimester; T3—3rd trimester.

Fig 1 Comparison of gut bacterial α-diversity between the GDM group and control group in the second trimester (T2) and the third trimester (T3) of pregnancy

图2 孕中期（T2）至孕晚期（T3）GDM组和对照组孕妇肠道菌群β-多样性比较Note： A. GDM group and control group in T2. B. GDM group and control group in T3. C. GDM group in T2 and T3. D. Control group in T2 and T3. GDM—GDM group; CON—Control group; T2—2nd trimester; T3—3rd trimester.

Fig 2 Comparison of gut bacterial β-diversity between the GDM group and control group in the second trimester (T2) and the third trimester (T3) of pregnancy

图3 在孕中期与孕晚期的2组孕妇中总丰度前20的肠道菌属的热图聚类分析Note：Color gradients show variations in the abundance of different bacteria among the four groups.

Fig 3 Heatmap clustering analysis of the top 20 gut bacterial genera in the women of the two groups in the second trimester (T2) and the third trimester (T3) of pregnancy

图4 在孕中期与孕晚期的2组孕妇中总丰度前20的属水平菌群的差异检验Note： A. GDM group and control group in T2. B. GDM group and control group in T3. C. GDM group in T2 and T3. D. Control group in T2 and T3. GDM—GDM group; CON—Control group; T2—2nd trimester; T3—3rd trimester.

Fig 4 Difference test of the top 20 gut bacterial genera in the women of the two groups in the second trimester (T2) and the third trimester (T3) of pregnancy

图5 LEfSe分析GDM组和对照组孕妇肠道菌群的显著性差异物种Note： A. GDM group and control group in T2. B. GDM group and control group in T3. C. GDM group in T2 and T3. GDM—GDM group; CON—Control group; T2—2nd trimester; T3—3rd trimester.

Fig 5 LEfSe analysis of significantly different species of gut microbiota in the pregnant women of the GDM group and control group

图 6 孕中期环境因子与孕妇主要肠道菌群（相对丰度前20）的科水平（A）与属水平（B）的Spearman相关性热图分析Note： Blue represents negative correlation, red represents positive correlation, and the shade of the colour represents the magnitude of the coefficient correlation. *P<0.05.

Fig 6 Spearman correlation analysis between the environmental factors and the family level (A) and the genus level (B) of the gut microbiota (top 20) of the pregnant women in the second trimester (T2) of pregnancy

参考文献 26

1	American Diabetes Association. Diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 2010, 33(Suppl 1): S62-69.
2	ZHU Y Y, ZHANG C L. Prevalence of gestational diabetes and risk of progression to type 2 diabetes: a global perspective[J]. Curr Diab Rep, 2016, 16(1): 7.
3	GAO C H, SUN X, LU L, et al. Prevalence of gestational diabetes mellitus in mainland China: a systematic review and meta-analysis[J]. J Diabetes Investig, 2019, 10(1): 154-162.
4	DALY B, TOULIS K A, THOMAS N, et al. Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: a population-based cohort study[J]. PLoS Med, 2018, 15(1): e1002488.
5	MAHAJAN A, DONOVAN L E, VALLEE R, et al. Evidenced-based nutrition for gestational diabetes mellitus[J]. Curr Diab Rep, 2019, 19(10): 94.
6	ARRIETA M C, STIEMSMA L T, DIMITRIU P A, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma[J]. Sci Transl Med, 2015, 7(307): 307ra152.
7	STANISLAWSKI M A, DABELEA D, WAGNER B D, et al. Gut microbiota in the first 2 years of life and the association with body mass index at age 12 in a Norwegian birth cohort[J]. mBio, 2018, 9(5): e01751-e01718.
8	CRUSELL M K W, HANSEN T H, NIELSEN T, et al. Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum[J]. Microbiome, 2018, 6(1): 89.
9	ZHENG W, XU Q, HUANG W Y, et al. Gestational diabetes mellitus is associated with reduced dynamics of gut microbiota during the first half of pregnancy[J]. mSystems, 2020, 5(2): e00109-e00120.
10	WANG J F, ZHENG J Y, SHI W Y, et al. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus[J]. Gut, 2018, 67(9): 1614-1625.
11	HUANG L L, THONUSIN C, CHATTIPAKORN N, et al. Impacts of gut microbiota on gestational diabetes mellitus: a comprehensive review[J]. Eur J Nutr, 2021, 60(5): 2343-2360.
12	ROLD L S, BUNDGAARD-NIELSEN C, NIEMANN HOLM-JACOBSEN J, et al. Characteristics of the gut microbiome in women with gestational diabetes mellitus: a systematic review[J]. PLoS One, 2022, 17(1): e0262618.
13	中华医学会妇产科学分会产科学组, 中华医学会围产医学分会妊娠合并糖尿病协作组. 妊娠合并糖尿病诊治指南(2014)[J]. 中华妇产科杂志, 2014, 49(8): 561-569.
	Obstetrics Group of Obsterics and Gynecology Branch of Chinese Medical Association, Gestational Diabetes Mellitus Collaborative Group of Perinatal Medical Branch of Chinese Medical Association. Guidelines for diagnosis and treatment of pregnancy associated with diabetes[J]. Chin J Obstet Gynecol, 2014, 49(8): 561-569.
14	王蓓, 沈丽蔚, 周丽莉, 等. 孕期胆碱摄入及母婴体内胆碱代谢水平的相关性[J]. 中华围产医学杂志, 2017, 20(11): 790-795.
	WANG B, SHEN L W, ZHOU L L, et al. Association between choline intake during pregnancy and choline metabolism in parturients and infants[J]. Chin J Perinat Med, 2017, 20(11): 790-795.
15	JIA J, XUN P C, WANG X L, et al. Impact of postnatal antibiotics and parenteral nutrition on the gut microbiota in preterm infants during early life[J]. JPEN J Parenter Enteral Nutr, 2020, 44(4): 639-654.
16	CORTEZ R V, TADDEI C R, SPARVOLI L G, et al. Microbiome and its relation to gestational diabetes[J]. Endocrine, 2019, 64(2): 254-264.
17	FERROCINO I, PONZO V, GAMBINO R, et al. Changes in the gut microbiota composition during pregnancy in patients with gestational diabetes mellitus (GDM)[J]. Sci Rep, 2018, 8(1): 12216.
18	MEDICI DUALIB P, OGASSAVARA J, MATTAR R, et al. Gut microbiota and gestational diabetes mellitus: a systematic review[J]. Diabetes Res Clin Pract, 2021, 180: 109078.
19	LIU H, PAN L L, LV S T, et al. Alterations of gut microbiota and blood lipidome in gestational diabetes mellitus with hyperlipidemia[J]. Front Physiol, 2019, 10: 1015.
20	TAN J, MCKENZIE C, POTAMITIS M, et al. The role of short-chain fatty acids in health and disease[J]. Adv Immunol, 2014, 121: 91-119.
21	VITAL M, KARCH A, PIEPER D H. Colonic butyrate-producing communities in humans: an overview using omics data[J]. mSystems, 2017, 2(6): e00130-e00117.
22	ZHANG X Y, SHEN D Q, FANG Z W, et al. Human gut microbiota changes reveal the progression of glucose intolerance[J]. PLoS One, 2013, 8(8): e71108.
23	BORGO F, GARBOSSA S, RIVA A, et al. Body mass index and sex affect diverse microbial niches within the gut[J]. Front Microbiol, 2018, 9: 213.
24	STRAUB T J, CHOU W C, MANSON A L, et al. Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections[J]. BMC Microbiol, 2021, 21(1): 53.
25	MANCO M, PUTIGNANI L, BOTTAZZO G F. Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk[J]. Endocr Rev, 2010, 31(6): 817-844.
26	CANI P D, NEYRINCK A M, FAVA F, et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia[J]. Diabetologia, 2007, 50(11): 2374-2383.

[1]	刘芊若, 方子晨, 吴宇涵, 钟羡欣, 国沐禾, 贾洁. 肠道菌群及其代谢产物与妊娠期糖尿病相关性的研究进展[J]. 上海交通大学学报（医学版）, 2023, 43(5): 641-647.
[2]	张越, 瞿蕾, 谷沁, 朱亦清, 马莉莹, 孙文广. 妊娠期糖尿病孕妇尿酮体持续阳性对母婴临床结局的影响[J]. 上海交通大学学报（医学版）, 2023, 43(3): 314-319.
[3]	高菲, 卢宇, 董书琴, 杨柳, 吴邵花, 韦静. 孕早期成纤维生长因子19亚族对妊娠期糖尿病的预测价值[J]. 上海交通大学学报（医学版）, 2022, 42(7): 898-903.
[4]	卢雨, 王昊, 巴乾. 肠道菌群在肝癌发生发展及治疗中的作用研究进展[J]. 上海交通大学学报（医学版）, 2022, 42(7): 939-944.
[5]	吴侠霏, 方婕, 漆洪波, 余昕烊. 妊娠期糖尿病对C57BL/6J子代成年鼠神经精神功能的影响[J]. 上海交通大学学报（医学版）, 2022, 42(4): 422-432.
[6]	谷沁, 夏英倩, 朱亦清, 马莉莹, 瞿蕾, 孙文广. 妊娠期糖尿病孕妇一日门诊饮食个体化指导对血糖控制、体质量增速和妊娠结局的影响分析[J]. 上海交通大学学报(医学版), 2022, 42(2): 185-191.
[7]	杨科峰, 贾洁, 丁天泽, 张硕, 李心怡, 祝捷, 刘玉红, 卢凌鹏, 吴慧. n⁃3多不饱和脂肪酸、汞与妊娠期糖尿病的关联[J]. 上海交通大学学报（医学版）, 2022, 42(12): 1739-1744.
[8]	蒋怡, 江平, 张明明, 房静远. 嗜黏蛋白阿克曼菌在肠道相关疾病中作用的研究进展[J]. 上海交通大学学报（医学版）, 2022, 42(10): 1490-1497.
[9]	吴丹, 葛莉萍. 妊娠期糖尿病患者基因DNA甲基化的研究进展[J]. 上海交通大学学报(医学版), 2021, 41(8): 1120-1124.
[10]	宋兵福, 丁彬彬, 张晓丽, 姚莉韵. 二甲双胍对喹硫平致精神分裂症患者糖脂代谢紊乱的疗效[J]. 上海交通大学学报(医学版), 2021, 41(6): 776-780.
[11]	岳江, 周勇, 徐华, 刘文, 韩晓凤, 毛青, 张继东, 麻静, 蒋捍东, 刘伟. 糖脂代谢在新型冠状病毒肺炎普通型和重型患者中的特点分析及比较[J]. 上海交通大学学报(医学版), 2021, 41(3): 355-359.
[12]	刘庆, 蔡雯, 张瑞晴, 卢聪, 张佳荣, 徐先明. 妊娠期脂质耐量试验在妊娠期糖尿病风险预测中的价值[J]. 上海交通大学学报(医学版), 2021, 41(2): 210-216.
[13]	袁瑞雪, 傅迎美, 禹顺英. 辅助性T细胞17和调节性T细胞在抑郁症中的作用机制研究进展[J]. 上海交通大学学报(医学版), 2021, 41(10): 1384-1388.
[14]	朱雅洁, 林慧, 陈茜, 赵奕然, 刘欣梅, 黄荷凤. 妊娠期糖尿病母亲所产新生儿脐带血皮质醇水平变化及其对子代健康的影响[J]. 上海交通大学学报(医学版), 2021, 41(1): 49-54.
[15]	周铖1，孙鹏飞2，尹继瑶3，王阳阳1，肖海娟4, 5. 粪菌移植治疗炎症性肠病的研究进展[J]. 上海交通大学学报（医学版）, 2020, 40(2): 267-.

妊娠期糖尿病女性肠道菌群的变化特征及其与血糖、血脂和膳食的相关性

Dynamic changes in gut microbiota of women with gestational diabetes mellitus and the correlation with blood glucose, blood lipid and diet

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 8

参考文献 26

相关文章 15

编辑推荐

Metrics