上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (12): 1407-.

• 专家论坛 • 上一篇    下一篇

光化学反应组织黏合技术与组织修复

姚 敏, 王 莹   

  1. 上海交通大学 医学院第三人民医院烧伤整形科 创伤医学研究所, 上海 201900
  • 出版日期:2009-12-25 发布日期:2009-12-25
  • 作者简介:姚 敏（1963—）, 女, 研究员, 博士, 博士生导师；电子信箱: yaomin1688@yahoo.com。

Photochemical tissue bonding in tissue repair

YAO Min, WANG Ying   

  1. Department of Burn and Plastic Surgery, Institute of Traumatic Medicine, The Third People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201900, China
  • Online:2009-12-25 Published:2009-12-25

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摘要：

缝合术是临床常规应用的组织修复技术，但缝线（针）作为一种异物，可能引发患者不同程度的免疫反应，也是术后感染的诱因之一。缝合作为额外的损伤，可增加局部组织炎症反应并残留针眼瘢痕。文章介绍一种新的免缝合组织黏合技术——光化学反应组织黏合技术，即利用可见光激活光敏剂后使组织胶原之间形成交联而黏合组织。目前，该项技术已应用于皮肤、血管、神经、角膜等组织的损伤修复，可明显减轻炎症反应和瘢痕形成，降低血管吻合后的渗漏及吻合口狭窄的发生率，并能促进神经修复后功能的恢复。

关键词: 光化学反应组织黏合技术, 皮肤组织愈合, 角膜修复, 血管修复, 神经修复

Abstract:

Suture was a traditional method for tissue repair. However, sutures used in the closure of surgical wounds can induce inflammation and lead to scarring that appears as crosshatch marks. Threads used for sutures may cause immune response and surgical infection. In this review, we introduce a novel sutureless technique for wound repair, called photochemical tissue bonding (PTB). Absorption of visible light by a photosensitizing dye initiates photochemical reactions leading to covalent protein-protein crosslinks that bridge the wound surfaces, thus producing an immediate seal between the wound surfaces. This technique has been applied in various tissues including skin, cornea, nerve, blood vessels, et al. PTB reduces inflammation resulting in less scarring in skin. PTB dramatically improves the incidences of vascular anastomotic leakage and stricture. In addition, PTB enhances the recovery of nerve function after nerve repair.

Key words: photochemical tissue bonding, skin tissue repair, cornea repair, vascular repair, nerve repair