上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (8): 978-.

• 论著（临床研究） • 上一篇    下一篇

性别对卒中后失语症的影响

陈 莺, 李焰生   

  1. 上海交通大学 医学院仁济医院神经内科, 上海 200127
  • 出版日期:2009-08-25 发布日期:2009-09-27
  • 作者简介:陈莺（1977—）, 女, 上海人, 主治医师, 硕士生；电子信箱: ccicy@sohu.com。

Effects of gender on post-stroke aphasia

CHEN Ying, LI Yan-sheng   

  1. Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
  • Online:2009-08-25 Published:2009-09-27

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摘要：

目的 分析性别对卒中后失语（PSA）的发生率、失语类型、严重程度以及恢复速度的影响。 方法 选择符合入选标准的急性PSA患者110例，应用西部失语成套测验进行失语评估和分类，应用波士顿诊断性失语检查进行失语症严重程度分级。对未接受特殊语言治疗的44例患者在12周后进行语言评估。 结果 中年组（51～70岁）PSA患者中以男性居多，而老年组（>70岁）则以女性为多（P<0.05）。不同失语类型间无性别差异，均以完全性和运动性失语最常见。左右半球病变引起的PSA患者的性别比无统计学差异（P=0.062），但女性右侧半球病变时发生失语的概率有更高的趋势。相关分析显示12周后失语指数（AQ）改善分值仅与性别相关（r=0.303, P<0.05）。 结论 男女患者的两半球结构差异和行为差异可能导致不同半球病变时失语症发生概率和恢复速度的差异。

关键词: 卒中, 失语症, 性别

Abstract:

Objective To analyse the effects of gender on the prevalence, disease type, severity and recovery rate of post-stroke aphasia (PSA). Methods One hundred and ten patients with acute PSA were enrolled, the Western Aphasia Battery was employed for the evaluation and classification of aphasia, and the Boston Diagnostic Aphasia Test was adopted for the severity grading of aphasia. Forty-four patients without specific speech therapy were evaluated again 12 weeks later. Results There were more male patients with PSA than female ones in the middleaged group（51 to 70 years old), while there were more female patients in the elderly group（>70 years old）（P<0.05）. There was no significant difference in the types of aphasia between males and females, and the global aphasia and motor aphasia were the most common types of acute PSA for both sex.  Although there was no significant difference in the gender distribution between right hemisphere lesion-induced and left hemisphere lesion-induced PSA (P=0.062), there was a tendency that female patients were more likely to suffer from PSA when lesions located in the right hemisphere. It was revealed by correlation analysis that the improved scores on aphasia quotient (AQ) 12 weeks later were only related to sex（r=0.303, P<0.05）. Conclusion The differences in brain structure and behavior between males and females may cause differences in the prevalence and recovery rate of PSA.

Key words: stroke, aphasia, sex

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