上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (12): 1621-.doi: 10.3969/j.issn.1674-8115.2012.12.021

• 论著（临床研究） • 上一篇    下一篇

抗血管内皮生长因子联合光动力疗法治疗黄斑变性的系统分析

周 佳, 陆 琼   

  1. 上海交通大学 医学院附属瑞金医院卢湾分院眼科, 上海 200020
  • 出版日期:2012-12-28 发布日期:2012-12-31
  • 通讯作者: 陆 琼, 电子信箱: luqiong99@sina.com。
  • 作者简介:周 佳（1982—）, 女, 主治医师, 硕士；电子信箱: irench@163.com。

Meta-analysis of anti-vascular endothelial growth factor combined with photodynamic therapy in treatment of age-related macular degeneration

ZHOU Jia, LU Qiong   

  1. Department of Ophthalmology, Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China
  • Online:2012-12-28 Published:2012-12-31

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摘要：

目的 探讨抗血管内皮生长因子(VEGF)联合光动力疗法(PDT)治疗黄斑变性的效果与安全性，并作系统评价。方法 计算机检索Medline、Elsevier与中国生物医学文献数据库2001年1月—2011年8月的文献，检索语言限定为中、英文，纳入抗VEGF联合PDT治疗黄斑变性的随机对照试验（RCT），按照Cochran系统评价方法选择试验，提取有效数据进行系统评价。结果 共纳入7个RCT，包括496只黄斑变性眼，试验组和对照治疗组的比较结果显示：试验组在最佳矫正视力(BCVA)的视力预后中优势不明显，而在重复治疗次数中有明显的优势，而并发症的发生率并没有显著上升。结论 抗VEGF联合PDT治疗黄斑变性是有效和安全的。

关键词: 抗血管内皮生长因子, 光动力疗法, 年龄相关性黄斑变性, 联合治疗

Abstract:

Objective To investigate and systematically evaluate the effectiveness and safety of anti-vascular endothelial growth factor (VEGF) combined with photodynamic therapy (PDT) in the treatment of age-related macular degeneration. Methods Randomised controlled trials (RCT) of anti-VEGF combined with PDT in the treatment of age-related macular degeneration between January 2001 and August 2011 were searched in Medline, Elservier and Chinese Biomedical Literature Database, with the language limitation in English and Chinese. RCTs were included in accordance with the Cochrane review's methodology, the valid data were extracted, and the systematic analysis was conducted. Results Seven RCTs were enrolled, including 496 eyes with agerelated macular degeneration. Compared with monotherapy group, combination therapy group had advantage in the times of retreatment, but not in the best-corrected visual acuity. There was no significant difference in the prevalence of complications between two groups. Conclusion Anti-VEGF combined with PDT is effective and safe in the treatment of age-related macular degeneration.

Key words: anti-vascular endothelial growth factor, verteporfin photodynamic therapy, age-related macular degeneration, combination therapy