上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (3): 296-.doi: 10.3969/j.issn.1674-8115.2012.03.013

• 论著（临床研究） • 上一篇    下一篇

血浆抵抗素、高敏C反应蛋白与动脉硬化的关系

李发红, 魏方菲, 邹 军, 王继光, 李 燕   

  1. 上海交通大学 医学院附属瑞金医院 上海市高血压研究所, 上海 200025
  • 出版日期:2012-03-28 发布日期:2012-03-28
  • 通讯作者: 李 燕, 电子信箱: liyanshcn@yahoo.com。
  • 作者简介:李发红（1983—）, 女, 硕士生；电子信箱: fahongli58@gmail.com。
  • 基金资助:

    国家自然科学基金（30871081）

Association of arteriosclerosis with plasma resistin and high sensitive C-reactive protein

LI Fa-hong, WEI Fang-fei, ZOU Jun, WANG Ji-guang, LI Yan   

  1. Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-03-28 Published:2012-03-28
  • Supported by:

    National Natural Science Foundation of China, 30871081

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摘要：

目的 探讨比较血浆抵抗素和高敏C反应蛋白（hs-CRP）与动脉硬化的关系。方法 邀请在上海市高血压研究所接受动态血压监测的368名受检者参加研究，其中高血压患者未服用降压药物至少2周以上。检测臂踝脉搏波传导速度（baPWV），酶联免疫吸附试验检测血浆抵抗素和hs-CRP的质量浓度。运用相关分析和多元线性回归方法分析血浆炎症因子与动脉硬化的关系。结果 在简单相关分析及校正了年龄、性别、体质量指数、收缩压等因素的偏相关分析中，血浆抵抗素与baPWV均无相关性（r≤0.04，P≥0.44），而hs-CRP与baPWV显著正相关（r≥0.13，P≤0.02）。多元逐步回归分析结果显示：年龄和收缩压二者共同解释了baPWV值42%的变异，而hs-CRP只解释了baPWV值0.7%的变异。结论 血浆炎症因子hs-CRP浓度与动脉硬化独立相关；而血浆抵抗素水平与动脉硬化无相关性。动脉硬化的主要影响因素是年龄和收缩压增高，炎症的作用可能较小。

关键词: 高血压, 动脉硬化, 炎症, 抵抗素, C反应蛋白, 脉搏波传导速度

Abstract:

Objective To explore the association of arteriosclerosis with plasma resistin and high sensitive C-reactive protein (hs-CRP). Methods Three hundred and sixty-eight subjects undergoing ambulatory blood pressure monitoring at Shanghai Institute of Hypertension were enrolled, and all subjects had not taken antihypertensive drugs for at least 2 weeks. Brachial-ankle pulse wave velocity (baPWV) was measured, and plasma concentrations of resistin and hs-CRP were examined with enzyme linked immunosorbent assay. Correlation analysis and multiple linear regression analysis were used to analyse the association between plasma inflammation markers and arteriosclerosis. Results Hs-CRP (r≥0.13, P≤0.02), but not resistin (r≤0.04, P≥0.44), was significantly associated with baPWV in both simple and partial correlation analyses after adjustment for age, sex, body mass index and systolic blood pressure. Multiple stepwise regression analysis revealed that age and systolic blood pressure accounted for 42% of the variation of baPWV, while hs-CRP only explained 0.7% of the variation. Conclusion Plasma hs-CRP, but not resistin, is independently associated with arteriosclerosis. Aging and elevated systolic blood pressure are major determinants of arteriosclerosis, while inflammation has less impact on arteriosclerosis.

Key words: hypertension, arteriosclerosis, inflammation, resistin, C-reactive protein, pulse wave velocity