上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (2): 231-.doi: 10.3969/j.issn.1674-8115.2013.02.021

• 综述 • 上一篇    下一篇

非典型抗精神病药物对脂联素的影响

杨 琳1,2, 陈剑华2, 徐一峰2   

  1. 1.复旦大学附属华山医院精神医学教研室, 上海 200021； 2.上海交通大学 医学院附属精神卫生中心, 上海 200030
  • 出版日期:2013-02-28 发布日期:2013-03-07
  • 作者简介:杨 琳（1979—）, 女, 硕士生； 电子信箱: yanglin828@yahoo.com.cn。
  • 基金资助:

    国家自然科学基金面上项目（81171271）；上海市科委自然基金项目（11ZR1431300）；国家临床重点专科-上海市精神卫生中心（卫生部医政司2011-873）

Impact of atypical antipsychotics on adiponectin

YANG Lin1,2, CHEN Jian-hua2, XU Yi-feng2   

  1. 1.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai 200021, China； 2.Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2013-02-28 Published:2013-03-07
  • Supported by:

    National Natural Science Foundation of China, 81171271； Shanghai Science and Technology Committee Foundation, 11ZR1431300； National Key Clinical Disciplines at Shanghai Mental Health Center, Office of Medical Affairs, the Ministry of Health of China, 2011-873

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摘要：

非典型抗精神病药物(AAPs)可导致代谢综合征（MS），其相关机制尚未完全阐明。脂肪组织通过分泌脂肪因子调控机体能量代谢。研究表明AAPs对脂肪因子的影响是药源性MS的潜在机制之一，而脂联素是一种与MS发病关系密切的脂肪因子。文章综述AAPs所致MS与脂联素的关系。

关键词: 非典型抗精神病药物, 代谢综合征, 脂肪因子, 脂联素

Abstract:

Metabolic syndrome (MS) may be caused by atypical antipsychotics (AAPs), and the possible mechanisms have not been fully revealed. Adipocytes regulate energy metabolism through release of adipocytokines. Studies have demonstrated that the impact of AAPs on adipokines is one of the potential mechanisms of drug-induced MS, and adiponectin is an important adipocytokine closely related to MS. The association between AAPs-induced MS and adiponectin is reviewed in this paper.

Key words: antipsychotics, metabolic syndrome, adipocytokines, adiponectin