上海交通大学学报（医学版）

上海交通大学学报（医学版）

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COPD合并认知功能损害与阿尔兹海默病的关系

於苏莉1，周 敏2   

  1. 上海交通大学  医学院附属瑞金医院 1.康复科, 2.呼吸科， 上海 200025
  • 出版日期:2014-01-28 发布日期:2014-01-29
  • 作者简介:於苏莉（1989—）， 女， 硕士生; 电子信箱: hadgnj@gmail.com。

Correlation between COPD with cognitive dysfunction and Alzheimer′s disease

YU Su-li1, ZHOU Min2   

  1. 1.Department of Rehabilitation, 2.Department of Respiratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-01-28 Published:2014-01-29

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摘要：

慢性阻塞性肺疾病（COPD）导致认知功能损害的具体机制尚未完全清楚，现在普遍接受的说法是阻塞性肺功能障碍导致机体血氧浓度下降和（或）血碳酸浓度升高，对神经细胞造成损伤，导致认知功能下降。在缺氧的应激条件下，机体应答释放出一系列炎症因子损伤作用于内皮细胞，随后造成神经元的损伤。近年的研究指出，慢性缺氧也是阿尔兹海默病的高危因素之一。鉴于COPD合并认知功能损害与阿尔兹海默病之间存在的共同危险因素，该文对二者的相关性作简要阐述。

关键词: 慢性阻塞性肺疾病, 认知损害, 慢性缺氧, 内皮功能紊乱, 阿尔兹海默病

Abstract:

Cognitive dysfunction is very common in chronic obstructive pulmonary disease (COPD) patients, but the mechanism has not been illustrated clearly. The common thought internationally is that chronic hypoxia and/or hypercarbia play important roles in the process of neuron damage. Hypoxia activates body′s inflammatory response and releases a series inflammatory factors that contribute to the endothelial dysfunction and neuron damage. Recent years, many reports pointed out that the chronic hypoxia is a high risk factor in the progress of Alzheimer′s disease. The current studies of the relation between COPD with cognitive dysfunction and dementia of Alzheimer′s disease are reviewed in this article.

Key words: chronic obstructive pulmonary disease, cognitive dysfunction, chronic hypoxia, cerebral endothelial dysfunction, Alzheimer′s disease