上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

不同类型牙周炎患者牙龈组织中IL-17的表达研究

郭秋曼，束 蓉   

  1. 上海交通大学 医学院附属第九人民医院牙周科  上海市口腔医学重点实验室, 上海 200011
  • 出版日期:2014-10-28 发布日期:2014-10-28
  • 通讯作者: 束 蓉, 电子信箱: shurong123@hotmail.com。
  • 作者简介:郭秋曼（1982—）, 女， 住院医师， 硕士生; 电子信箱: sukeseki@126.com。

Study on expressions of IL-17 in gingival tissue of patients with different types of periodontitis

GUO Qiu-man, SHU Rong   

  1. Department of Periodontitis,the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011， China
  • Online:2014-10-28 Published:2014-10-28

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摘要：

目的 通过检测白介素-17（IL-17）在不同类型牙周炎患者牙龈组织中的分布以及表达水平，初步探讨IL-17在牙周炎发生和发展中的可能作用。方法 牙龈组织标本分为对照组（n=10）、慢性牙周炎组（n=10）和侵袭性牙周炎组（n=10）。采用免疫组织化学方法检测各组牙龈组织中IL-17的分布和表达水平。结果 IL-17在牙龈上皮和结缔组织全层中均有表达。慢性牙周炎组和侵袭性牙周炎组牙龈组织中IL-17表达水平均显著高于对照组（P<0.01）。侵袭性牙周炎组牙龈上皮和牙龈结缔组织中IL-17表达水平均显著高于慢性牙周炎组（P<0.01）。结论 IL-17参与牙周炎炎症反应的发生和发展，其在不同类型牙周炎患者牙龈组织中的表达存在差异。

关键词: 白介素-17, 慢性牙周炎, 侵袭性牙周炎, 牙龈

Abstract:

Objective To detect the distribution and expression of IL-17 in the gingival tissue of patients with different types of periodontitis and to preliminary explore the possible effects of IL-17 on the occurrence and development of periodontitis. Methods Gingival biopsies were divided into the control group (n=10), chronic periodontitis group (n=10), and aggressive periodontitis group(n=10). The distribution and expression of IL-17 in the gingival tissue of each group were detected by the immunohistochemistry. Results IL-17 expressed in the gingival epithelium and connective tissue full layer. The expressions of IL-17 in the gingival tissue of the chronic periodontitis group and aggressive periodontitis group were significantly higher than that of the control group (P<0.01). The expressions of IL-17 in the gingival epithelium and connective tissue of the aggressive periodontitis group were significantly higher than those of the chronic periodontitis group (P<0.01). Conclusion IL-17 involves in the occurrence and development of periodontal inflammation. The expressions of IL-17 in the gingival tissue of patients with different types of periodontitis are different.

Key words: interleukin-17, chronic periodontitis, aggressive periodontitis, gingival