上海交通大学学报（医学版）

上海交通大学学报（医学版）

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SUMO特异性蛋白酶家族的结构、分布、功能和调控

缪 语1，赵文博1，李 青2，易 静3，韩 艳2   

  1. 上海交通大学 1.基础医学院, 上海 200025； 2.医学院附属瑞金医院感染科, 上海 200025； 3.医学院生物化学与分子细胞生物学系, 上海 200025
  • 出版日期:2014-11-28 发布日期:2014-12-02
  • 作者简介:缪 语（1993—）， 男， 2011级本科生; 电子信箱: miaoyuno1@yahoo.com。
  • 基金资助:

    国家自然科学基金（81302086）；高等学校博士学科点专项科研基金（20130073120007）；上海市科技人才计划项目浦江人才A类项目（13PJ1406100）

Structure, location, function, and regulation of SUMO specific protease family

MIAO Yu1, ZHAO Wen-bo1, LI Qing2, YI Jing3, HAN Yan2   

  1. 1.Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China; 2.Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3.Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-11-28 Published:2014-12-02
  • Supported by:

    National Natural Science Foundation of China, 81302086; Special Scientific Research Foundation for University Doctorate of China, 20130073120007; Type A Project of Shanghai Pujiang Program of Shanghai Scientific and Technological Talents Project, 13PJ1406100

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摘要：

蛋白质的翻译后修饰对调节蛋白质的功能活性和定位以及调控细胞周期进程和细胞分化都起着非常重要的作用，其中小泛素样修饰蛋白（SUMO）化修饰是一个可以由SUMO特异性蛋白酶（SENPs）家族逆转的高度动态的过程。SENPs能够从与SUMO连接的靶蛋白上催化去除SUMO，以及从它的前体蛋白上裂解SUMO；同时，此家族部分成员还参与SUMO的成熟活化过程；因此，去SUMO化修饰对于调节SUMO连接蛋白的功能及活性与SUMO化同样重要。本文就SENPs家族的结构及生物学特性作一综述。

关键词: SUMO化修饰, 去SUMO化修饰, SUMO特异性蛋白酶, Ulp, Ulp功能域

Abstract:

Post-translational modification of proteins plays a very important role in regulating function, activity and positioning of proteins, as well as the progression of cell cycle and cell differentiation. SUMOylation (SUMO, small ubiquitin-like modifier) is a highly dynamic process which can be reserved by SUMO specific proteases (SENPs) family. SENPs can catalyze and remove SUMO from SUMO-connecting target proteins, as well as from their precursor proteins. Furthermore, some members of this family are involved in the maturation and activation of SUMO. Thus, deSUMOylation is as important as SUMOylation to the regulation of function and activity of SUMO-connecting proteins. This paper reviews the structure and biological characteristics of SENPs family.

Key words: SUMOylation, deSUMOylation, SUMO specific protease, Ulp, Ulp domain