上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (9): 1292-.doi: 10.3969/j.issn.1674-8115.2017.09.018

• 综述 • 上一篇    下一篇

基因敲除动物模型在强迫症研究中的应用与进展

王佩，许婷婷，赵青，王振   

  1. 上海交通大学 医学院附属精神卫生中心，上海 200030
  • 出版日期:2017-09-28 发布日期:2017-10-10
  • 作者简介:王佩（1992—），女，硕士生；电子信箱：1351112099@qq.com
  • 基金资助:
     国家自然科学基金（81671340）；上海市教育委员会高峰高原学科建设计划（20161321）

Application and development of genetic knockout animal models in researches of obsessive-compulsive disorder#br#

WANG Pei, XU Ting-ting, ZHAO Qing, WANG Zhen   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2017-09-28 Published:2017-10-10
  • Supported by:
     National Natural Science Foundation of China, 81671340; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support, 20161321

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摘要： 近年来，强迫症（OCD）的临床研究取得了一定进展。但由于人体研究的非侵入性等特点，很大程度上限制了对 OCD 的深 入研究。动物模型可以突破人体研究的这一缺陷，使更精确地研究 OCD 的病理生理学机制成为可能。因而，众多的研究者试图采用 基因敲除动物模型对 OCD 的发病机制进行更深入的探讨。该文主要对此类研究及其进展进行综述。

关键词: 强迫症, 动物模型, 基因敲除

Abstract:

Recently, some progress has been made in the clinical study of obsessive compulsive disorder (OCD). Human research has inherent limitation because of its non-invasive nature, while animal models can break through the shortcomings of human research, allowing us to more accurately study the pathophysiology of OCD. Therefore, many researchers tried to use genetic knockout animal models to further study the etiology of OCD. In this review, recent progress about this kind of research was reviewed. [

Key words: obsessive-compulsive disorder, animal model, gene knockout