上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (4): 477-.doi: 10.3969/j.issn.1674-8115.2018.04.024

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过氧化物酶体增殖物激活受体在视神经保护中的作用

施丹莉，王若冰，柳林   

  1. 上海交通大学医学院附属仁济医院眼科，上海 200127
  • 出版日期:2018-04-28 发布日期:2018-05-03
  • 通讯作者: 柳林，电子信箱：liulin1963rj@126.com。
  • 作者简介:施丹莉（1991—），女，硕士生；电子信箱：sdlmed@163.com。
  • 基金资助:
    上海市卫生和计划生育委员会科研课题（M201440522）

Effect of peroxisome proliferator-activated receptors in optic nerve protection

SHI Dan-li , WANG Ruo-bing, LIU Lin   

  1. Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2018-04-28 Published:2018-05-03
  • Supported by:
    Research Project of Shanghai Municipal Commission of Health and Family Planning, M201440522

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摘要： 视神经具有损伤后不可修复再生的特殊性。在视神经相关疾病中，视网膜神经节细胞坏死、凋亡、轴突丢失，继而导致不可逆性的视觉损伤。过氧化物酶体增殖物激活受体（peroxisome proliferator-activated receptors，PPARs）经相应配体激活后，对外周器官及中枢神经系统急慢性损伤具有潜在的神经保护作用。视神经属间脑白质在外周的延伸，其病理生理过程与中枢神经系统具有相似之处，从而使PPARs在视神经保护中的作用成为眼科领域关注的热点。文章就PPARs在眼科领域对视神经损伤的保护作用及其可能机制的研究进展进行综述。

关键词: 过氧化物酶体增殖物激活受体, 视神经保护, 视网膜神经节细胞

Abstract:

Neuronal death is thought to be irreversible. In optic nerve-related diseases, the death and axonal loss of retinal ganglion cells could leadto irreversible visual impairment. A large number of studies support the hypothesis that the peroxisome proliferator-activated receptors (PPARs), onceactivatedparticular ligands, could have a potential neuroprotective effect on the peripheral organs and the central nervous system suffering acuteor chronic injury. Optic nerve belongs to the extension of white matter in the central nervous system and shares similar pathophysiological processes with the central nervous system, which makes PPARs a hot spot in the field of optic nerve protection. This paper reviewed the effect of PPARs in optic nerve protection and its possible mechanism.

Key words: peroxisome proliferator-activated receptors , optic nerve protection, retinal ganglion cells

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