上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (2): 160-.doi: 10.3969/j.issn.1674-8115.2019.02.010

• 论著·临床研究 • 上一篇    下一篇

血尿酸水平与亚临床靶器官损害的相关性研究

胡月亮 1，马瑾 2，唐碧雯 1，王潜 1，晁慧娟 1，宣言 1，左君丽 1   

  1. 1. 贵州医科大学贵州省普通高校病原生物学特色重点实验室，贵阳 550025；2. 上海交通大学基础医学院免疫学与微生物学系，上海 200025； 3. 复旦大学附属华东医院妇科，上海 200040；4. 上海交通大学医学院附属国际和平妇幼保健院检验科，上海 200030
  • 出版日期:2019-02-28 发布日期:2019-03-19
  • 通讯作者: 左君丽，电子邮箱：zuo-junli@163.com。
  • 作者简介:胡月亮（1985—），女，主治医师，硕士；电子邮箱： 13701736245@163.com。
  • 基金资助:
    国家自然科学基金（ 81500190）；上海市卫生和计划生育委员会科研课题（ 20184Y0100；201740128；20154Y0053）；上海市嘉定区科委（ JDKW2017-W12）

Relationship between serum uric acid level and subclinical target organ damage

HU Yue-liang1, MA Jin2, TANG Bi-wen1, WANG Qian1, CHAO Hui-juan1, XUAN Yan1, ZUO Jun-li1   

  1. 1. Department of Geriatrics, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 201801,China; 2. Department of Cardiology,Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, China
  • Online:2019-02-28 Published:2019-03-19
  • Supported by:
    National Natural Science Foundation of China, 81500190；Shanghai Municipal Commission of Health and Family Planning, 20184Y0100; 201740128; 20154Y0053; Shanghai Jiading Science and Technology Committee, JDKW-2017-W12

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摘要： 目的 ·探究血尿酸水平与亚临床靶器官损害的相关性。方法 ·入选体检人群 333例，测定其血尿酸，根据尿酸水平分为高尿酸组（ 85例）、正常组（ 248例）；测定其亚临床靶器官损害指标包括肾小球滤过率、左室重量指数等。通过相关分析及多元线性回归分析探讨尿酸水平与亚临床靶器官损害的关系。结果 ·高尿酸组的收缩压（ P0.006）、舒张压（ P0.000）、血肌酐（ P0.000）、左室重量指数（ P0.028）显著高于正常组，肾小球滤过率显著低于正常组（ P0.000）。Pearson相关性分析显示，血尿酸水平与收缩压（r0.149，P0.007）、舒张压（ r0.269，P0.000）、左室重量指数（ r0.172，P0.002）、血肌酐（ r0.569，P0.000）显著正相关，血尿酸水平与肾小球滤过率显著负相关（ r-0.383，P0.000）。进一步校正性别、年龄、体质量指数后，与舒张压仍呈显著正相关（r0.170，P0.013），与肾小球滤过率呈显著强负相关（ r-0.332，P0.000）。进一步校正血压后，与肾小球滤过率仍呈显著强负相关（ r-0.291，P0.000）。多元线性回归分析显示，血尿酸与舒张压呈独立正相关（ β0.162，P0.000），血尿酸与肾小球滤过率呈独立负相关（β-0.058，P0.004）。结论 ·血尿酸与舒张压呈独立正相关，血尿酸与肾小球滤过率呈独立负相关。

关键词: 血尿酸, 收缩压, 舒张压, 肾小球滤过率, 左室重量指数

Abstract:

Objective · To explore the correlation between serum uric acid level and subclinical target organ damage. Methods · A cohort of 333 patients were recruited at the Department of Examination Center of Ruijin Hospital North in July 2017, who were divided into two groups, normal (n248) and high levels (n85, males >420 μmol/L, females >360 μmol/L) of serum uric acid. Subclinical target organ damage indexes included glomerular filtration rate (eGFR), left ventricular mass index (LVMI) and other indicators. Results · Systolic pressure (P0.006), diastolic pressure (P0.000), serum creatinine (P0.000) and LVMI (P0.028) in the high uric acid group were significantly higher than those in the normal uric acid group, and eGFR was significantly lower than that of the control group (P0.000). Pearson correlation analysis showed that the serum uric acid level was significantly correlated with systolic pressure (r0.149, P0.007), diastolic pressure (r0.269, P0.000), LVMI (r0.172, P0.002) and serum creatinine (r0.569, P0.000), and negatively correlated with glomerular filtration rate (r-0.383, P0.000). After adjusting to sex, age, and BMI, there was a significant positive correlation with diastolic pressure (r0.170, P0.013), and a significant negative correlation with glomerular filtration rate (r-0.332, P0.000). After further adjusting to blood pressure, there was a significant negative correlation with glomerular filtration rate (r-0.291, P0.000). Multivariate linear regression analysis showed that serum uric acid was independent of diastolic pressure and glomerular filtration rate (β0.162, P0.000; β-0.058, P0.004). Conclusion · Serum uric acid is positively correlated with diastolic blood pressure, and is negatively correlated with glomerular filtration rate.

Key words: serum uric acid, systolic blood pressure, diastolic blood pressure, glomerular filtration rate, left ventricular mass index

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