羟氯喹应用于生殖免疫领域的研究进展

doi:10.3969/j.issn.1674-8115.2021.03.017

摘要/Abstract

摘要：

羟氯喹（hydroxychloroquine， HCQ）是人工合成的4-氨基喹啉类抗疟药。近年来，其调节免疫、免疫抑制、抗炎、保护血管内皮、预防血栓、降糖调脂、抗感染等多种药理作用逐渐为人所知。目前HCQ已成为治疗系统性红斑狼疮的一线用药，多个自身免疫疾病诊治指南将其列为妊娠期及哺乳期可全程使用药物。该文主要阐述了在生殖免疫领域包括妊娠合并系统性红斑狼疮、抗磷脂综合征、干燥综合征等自身免疫疾病，及不明原因习惯性流产和反复胚胎种植失败，应用HCQ的机制以及相关研究的进展，探讨HCQ应用于生殖免疫领域的安全性及前景。

关键词: 羟氯喹, 生殖免疫, 妊娠, 药物机制, 安全性

Abstract:

Hydroxychloroquine (HCQ) is a kind of synthetic 4-aminoquinoline antimalarial drugs. In recent years, other pharmacological effects of HCQ, such as immunomodulatory, immunosuppression, anti-inflammation, vascular endothelium protection, anti-thrombus, improving metabolic syndrome, and anti-infection, have been gradually known. At present, HCQ is a first-line drug for systemic lupus erythematosus. And in many guidelines for the treatment of autoimmune diseases, HCQ is recommended during whole pregnancy and lactation. This review mainly expounds the mechanism and research progress of HCQ in reproductive immunology, including pregnancy complicated with autoimmune diseases, such as systemic lupus erythematosus, antiphospholipid syndrome and Sjogren's syndrome, as well as unexplained recurrent spontaneous abortion and recurrent implantation failure, and explores the safety and application prospect of HCQ in reproductive immunology.

Key words: hydroxychloroquine (HCQ), reproductive immunology, pregnancy, drug mechanism, safety

中图分类号:

R714.259

寇禧, 赵爱民. 羟氯喹应用于生殖免疫领域的研究进展[J]. 上海交通大学学报(医学版), 2021, 41(3): 380-385.

Xi KOU, Ai-min ZHAO. Research progress of hydroxychloroquine in reproductive immunology[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(3): 380-385.

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