神经血管耦合在骨修复中作用的研究进展

doi:10.3969/j.issn.1674-8115.2024.03.010

上海交通大学学报（医学版） ›› 2024, Vol. 44 ›› Issue (3): 373-378.doi: 10.3969/j.issn.1674-8115.2024.03.010

• 综述 • 上一篇

神经血管耦合在骨修复中作用的研究进展

何姝航¹^,²^,³(), 郭尚春¹^,²^,³, 陶诗聪¹^,²()

^1.上海交通大学医学院附属第六人民医院骨科，上海 200233
^2.上海交通大学医学院附属第六人民医院临床医学院，上海 200233
^3.上海市四肢显微外科研究所，上海 200233

收稿日期:2023-08-13 接受日期:2024-02-09 出版日期:2024-03-28 发布日期:2024-04-29
通讯作者: 陶诗聪 E-mail:he_sh2023@163.com;sctao@shsmu.edu.cn
作者简介:何姝航（2000—），女，硕士生；电子信箱：he_sh2023@163.com。
基金资助:
国家自然科学基金(81802226);上海市浦江人才计划(2019PJD038);2020年上海市“医苑新星”青年医学人才培养资助计划;上海交通大学医学院“双百人”项目(2022-017);上海市第六人民医院优秀人才培育项目(ynyq202101)

Advances in the study of neurovascular coupling in bone repair

HE Shuhang¹^,²^,³(), GUO Shangchun¹^,²^,³, TAO Shicong¹^,²()

^1.Department of Orthopedic Surgery, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
^2.Clinical Medical College of Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
^3.Shanghai Institute of Microsurgery on Extremities, 200233, China

Received:2023-08-13 Accepted:2024-02-09 Online:2024-03-28 Published:2024-04-29
Contact: TAO Shicong E-mail:he_sh2023@163.com;sctao@shsmu.edu.cn
Supported by:
National Natural Science Foundation of China(81802226);Shanghai Pujiang Program(2019PJD038);Shanghai "Rising Stars of Medical Talent" Youth Development Program in 2020;"Two-hundred Talents" Program of Shanghai Jiao Tong University School of Medicine(2022-017);Shanghai Sixth People′s Hospital Excellent Young Scientist Development Program(ynyq202101)

摘要/Abstract

摘要：

骨修复是一个复杂的生理过程，骨内的神经通过释放生物活性分子以及与骨内细胞相互作用等方式调节骨组织再生。近年来，已经有研究尝试基于神经血管耦合进行生物材料设计，取得了有价值的成果。该文对神经与骨组织相互作用，以及利用神经血管耦合设计和制造可用于骨组织再生的生物活性材料的研究进展进行总结和探讨，为充分理解和利用神经血管耦合在骨修复中的功能提供新视角，为骨修复策略的研究及临床治疗提供新的思路。

关键词: 神经血管耦合, 骨修复, 骨内神经, 骨组织工程

Abstract:

Bone repair is a complex physiological process. The nerves within the bone can regulate bone tissue regeneration through the secretion of bioactive factors and interactions with cells within the bone. Recent studies have sought to leverage the principles of neurovascular coupling in the creation of bioactive materials, yielding promising results. This article reviews nerves and vessels within the bone, the role of neural signals in bone repair, and potential mechanisms of neurovascular coupling in bone repair, expecting to provide a thorough understanding on the function of neurovascular coupling in bone repair as well as fresh perspectives on the scientific research and clinical treatment of bone repair strategies.

Key words: neurovascular coupling, bone repair, nerves within bone, tissue engineering

中图分类号:

R683

何姝航, 郭尚春, 陶诗聪. 神经血管耦合在骨修复中作用的研究进展[J]. 上海交通大学学报（医学版）, 2024, 44(3): 373-378.

HE Shuhang, GUO Shangchun, TAO Shicong. Advances in the study of neurovascular coupling in bone repair[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(3): 373-378.

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神经血管耦合在骨修复中作用的研究进展

Advances in the study of neurovascular coupling in bone repair

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