上海交通大学学报(医学版)

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间充质干细胞对肿瘤的影响及其应用于肿瘤治疗的前景

高维岳,秦子顺,殷丽华,王家奎,刘 琪,余占海   

  1. 兰州大学口腔医学院, 兰州 730000
  • 出版日期:2014-03-28 发布日期:2014-04-02
  • 通讯作者: 余占海, 电子信箱: yuzhanhai@lzu.edu.cn。
  • 作者简介:高维岳(1986—),男,硕士生; 电子信箱: gwy9183583@163.com。
  • 基金资助:

    国家自然科学基金青年科学基金项目(81102712)

Effects of mesenchymal stem cells on tumor and prospects of oncotherapy

GAO Wei-yue, QIN Zi-shun, YIN Li-hua, WANG Jia-kui, LIU Qi, YU Zhan-hai   

  1. School of Stomatology, Lanzhou University, Lanzhou 730000, China
  • Online:2014-03-28 Published:2014-04-02
  • Supported by:

    Young Scientists Project of National Natural Science Foundation of China, 81102712

摘要:

间充质干细胞(MSCs)在肿瘤的发生中扮演着重要角色,但它对肿瘤生长的影响存在争议,不同的研究表明MSCs可以促进或抑制肿瘤生长。同时,因MSCs对肿瘤的趋向性及低免疫原性,使其具备了应用于肿瘤治疗的潜力。

关键词: 间充质干细胞, 肿瘤, 肿瘤治疗, 载体

Abstract:

Mesenchymal stem cells (MSCs) play an important role in tumorigenesis, but there are some disputes about their effects on the tumor growth. Different studies found that MSCs could promote or suppress the tumor growth. MSCs had the potential to be used for oncotherapy because of its tropism of tumor and low immunogenicity.

Key words: mesenchymal stem cells, tumor, oncotherapy, carrier